基于NLRP3炎症小体探讨针刺治疗阿尔茨海默病  

Acupuncture Treatment of Alzheimer′s Disease Based on NLRP3 Inflammasome

作　　者：王瑞奇 詹逸珺 裴建[1] WANG Ruiqi;ZHAN Yijun;PEI Jian(Department of Acupuncture and Moxibustion,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai China 200032)

机构地区：[1]上海中医药大学附属龙华医院针灸科,上海200032

出　　处：《中医学报》2024年第6期1171-1176,共6页Acta Chinese Medicine

基　　金：上海市科学技术委员会科研项目(22Y11922900,18401970500);上海市卫生健康委员会海派中医流派传承研究项目[ZY(2021-2023)-0209-10,ZY(2018-2020)-CCCX-1006];上海申康重大临床研究项目(SHDC2020CR3091B)。

摘　　要：持续过度的免疫炎症反应在阿尔茨海默病(Alzheimer′s disease,AD)的病理机制中发挥关键作用。核苷酸结合寡聚化结构域样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎症小体在神经炎症通路中至关重要,NLRP3炎症小体在β淀粉样蛋白(amyloidβ-protein,Aβ)等多种刺激下异常激活,触发AD的病理变化导致认知功能的下降,因此NLRP3炎症小体可能为AD的治疗提供新的靶点。针刺可通过调控TLR4/NF-κB信号通路、调节肠道菌群紊乱等方式抑制NLRP3炎症小体激活,从而抑制小胶质细胞活化及促炎细胞因子表达,进而发挥治疗AD的作用。未来可通过组学技术、高通量质谱分析和生物信息学等方法从多维角度进行研究,为针刺防治AD提供更有力的证据。Persistent excessive immune inflammatory response plays a key role in the pathogenesis of Alzheimer′s disease(AD).NOD-like receptor protein 3(NLRP3)inflammasome is crucial in neuroinflammatory pathways,which is abnormally activated by various stimuli such as amyloidβ-protein(Aβ)and triggers AD pathological changes,leading to the decline of cognitive function.NLRP3 inflammasome may provide a new target for the treatment of AD.Acupuncture can inhibit the activation of NLRP3 inflammasome by regulating TLR4/NF-κB signaling pathway and regulating intestinal flora disorder,thereby inhibiting the activation of microglia and the expression of pro-inflammatory cytokines,to play a role in the treatment of AD.In the future,omics technology,high-throughput mass spectrometry and bioinformatics can be used to study from multi-dimensional perspectives,to provide stronger evidence for the prevention and treatment of AD with acupuncture.

关 键 词：阿尔茨海默病 针刺 NLRP3炎症小体 神经炎症 

分 类 号：R245.742[医药卫生—针灸推拿学]