活血化瘀中药重塑肿瘤微环境  

Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis in Reshaping Tumor Microenvironment

作　　者：何伟[1] HE Wei(College of Basic Medicine,Shaanxi University of Chinese Medicine,Shaanxi Xianyang China 712046)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046

出　　处：《中医学报》2024年第6期1188-1194,共7页Acta Chinese Medicine

基　　金：陕西省教育厅科学研究计划-重点项目(20JS030,23JS007);陕西省重点研发计划项目(2021SF-402,2022SF-316)。

摘　　要：“血瘀”既是对机体整体血液高凝状态的病理归纳,也是对局部肿瘤微环境血脉病变的高度概括,是肿瘤中医病机认识的核心要素。活血化瘀类中药具有抑制肿瘤细胞生长、增殖、侵袭及转移等功效,能够通过诱导肿瘤细胞凋亡及自噬、抑制肿瘤相关成纤维细胞活化、抑制肿瘤新生血管增殖、改善血液高凝状态、阻止细胞外基质降解、改善缺氧微环境、纠正酸性微环境、抑制炎性微环境、调控免疫微环境等重塑肿瘤微环境。针对活血化瘀中药重塑肿瘤微环境的研究现状,今后需遵循中医辨治原则,注重肿瘤微环境时空异质性,阐释肿瘤微环境各成分间“正邪联动”效应机制,开展活血化瘀中药复方药效机制及临床疗效的真实世界研究,研发靶向肿瘤微环境纳米递药系统,以期为肿瘤病证的精准辨治提供指导。"Blood stasis"is not only a pathological induction of the overall hypercoagulable state of the body,but also a high generalization of the local tumor microenvironment of blood vessel lesions,which is the core element of the understanding of the pathogenesis of tumor in traditional Chinese medicine.Chinese herbs for promoting blood circulation and removing blood stasis can inhibit the growth,proliferation,invasion,and metastasis of tumor cells.It can reshape tumor microenvironment by inducing tumor cell apoptosis and autophagy,inhibiting tumor related fibroblast activation,inhibiting tumor neovascularization,improving blood hypercoagulability,preventing extracellular matrix degradation,improving hypoxia microenvironment,correcting acidic microenvironment,inhibiting inflammatory microenvironment,regulating immune microenvironment,etc.In view of the current research status on the remodeling of tumor microenvironment by activating blood circulation and removing blood stasis traditional Chinese medicine,future research should follow the principle of differentiation and treatment of traditional Chinese medicine,pay attention to the spatio-temporal heterogeneity of tumor microenvironment,explain the mechanism of"Zheng Qi and evil factor interaction"effect between various components of tumor microenvironment,carry out real-world research on the pharmacodynamic mechanism and clinical efficacy of activating blood circulation and removing blood stasis traditional Chinese medicine compound,and develop nano drug delivery systems targeting tumor microenvironment.To provide guidance for the accurate differentiation and treatment of tumor disease.

关 键 词：活血化瘀中药 肿瘤微环境 血瘀 

分 类 号：R285[医药卫生—中药学]