早孕期正常胎儿上颌及下颌多切面超声参考值的研究  

Study on ultrasound reference values for multi-sectional measurements of normal fetal maxilla and mandible in first trimester

作　　者：梁晓玲 王佳[2] 史惠铭 叶璐 LIANG Xiaoling;WANG Jia;SHI Huiming;YE Lu(Department of Ultrasound,Sichuan Provincial Maternity and Child Health Care Hospital,Chengdu 610000,China)

机构地区：[1]四川省妇幼保健院超声科,成都市610000 [2]郑州市妇幼保健院超声科 [3]牡丹江市妇幼保健院超声科 [4]四川大学华西第二医院超声科出生缺陷与相关妇儿疾病教育部重点实验室

出　　处：《临床超声医学杂志》2024年第5期400-405,共6页Journal of Clinical Ultrasound in Medicine

摘　　要：目的 应用超声对早孕期胎儿上颌及下颌进行多切面测量,初步建立早孕期正常胎儿上颌及下颌参数的参考值。方法 选取在我院进行早孕期超声检查的正常胎儿322例,应用超声测量胎儿顶臀长(CRL)、腭线长度、上颌横径、原发腭宽度、下颌横径、下颌前后径、下颌长度及下颌间隙,分析胎儿上颌及下颌各参数与孕周、CRL的相关性,并拟合线性回归方程。结果 322例胎儿腭线长度、上颌横径、原发腭宽度、下颌横径、下颌前后径、下颌长度、下颌间隙分别为7.3(6.5,8.0)mm、8.2(7.3,9.3)mm、6.3(4.8,7.5)mm、8.4(7.2,9.9)mm、4.5(3.4,5.7)mm、8.4(7.4,9.6)mm、2.1(1.7,2.7)mm。在上颌超声参数中,上颌横径与孕周、CRL的相关系数最高(r=0.658、0.664,均P<0.001),上颌横径与孕周、CRL的线性回归方程分别为:上颌横径(mm)=1.67×孕周-12.57;上颌横径(mm)=0.13×CRL+0.80。在下颌超声参数中,下颌横径与孕周、CRL的相关系数最高(r=0.704、0.698,均P<0.001),下颌横径与孕周、CRL的线性回归方程分别为:下颌横径(mm)=2.39×孕周-21.20;下颌横径(mm)=0.18×CRL-2.06。结论 本研究建立了早孕期正常胎儿上颌及下颌超声参考值,可为早孕期胎儿颌面部评估及发育异常筛查提供一定的参考价值。Objective To establish reference values for normal fetal maxillary and mandibular parameters in first trimester by multi-sectional ultrasound measurements.Methods A total of 322 normal fetuses underwent first-trimester ultrasound examination in our hospital were selected.Ultrasound measurements were performed for fetal crown-rump length(CRL),length of the palatal line,maxillary transverse diameter,primary palate width and transverse diameter,anteroposterior diameter,length and gap of the mandible.The correlation between each parameter of fetal maxilla and mandible with gestational age,CRL were analyzed,and the linear regression equations were fitted.Results In 322 cases,the length of the palatal line,maxillary transverse diameter,primary palatal width,transverse diameter of the mandible,anteroposterior diameter of the length of mandible,and gap of mandible were 7.3(6.5,8.0)mm,8.2(7.3,9.3)mm,6.3(4.8,7.5)mm,8.4(7.2,9.9)mm,4.5(3.4,5.7)mm,8.4(7.4,9.6)mm and 2.1(1.7,2.7)mm,respectively.Among maxillary parameters,maxillary transverse diameter had the highest correlation coefficient with gestational age and CRL(r=0.658,0.664,both P<0.001).The linear regression equations of maxillary transverse diameter and gestational age,CRL were as follow:maxillary transverse diameter(mm)=1.67×gestational age-12.57,maxillary transverse diameter(mm)=0.13×CRL+0.80.Among mandibular parameters,the transverse diameter of mandible had the highest correlation coefficient with gestational age and CRL(r=0.704,0.698,both P<0.001).The linear regression equations of mandibular transverse diameter and gestational age,CRL were as follow:mandibular transverse diameter(mm)=2.39×gestational age-21.20,mandibular transverse diameter(mm)=0.18×CRL-2.06.Conclusion This study establishes reference values for maxillary and mandible ultrasound of normal fetuses in first trimester,and it can provide a certain reference value for fetal maxillofacial assessment and screening of developmental abnormalities of fetuses in first trimester.

关 键 词：超声检查 正常胎儿 早孕期 上颌 下颌 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]