后生素调控动物肠道健康的作用机制及应用进展  

Research Progress on Mechanism and Application of Postbiotics in RegulatingAnimal IntestinalHealth

作　　者：张吉贤 范定坤 付域泽 焦帅 马涛[1] 毕研亮[1] 张乃锋[1] ZHANG Jixian;FAN Dingkun;FU Yuze;JIAO Shuai;MA Tao;BI Yanliang;ZHANG Naifeng(Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs,Institute of Feed Research of Chinese Academy of Agricultural Sciences,Beijing 100081,China)

机构地区：[1]中国农业科学院饲料研究所农业农村部饲料生物技术重点开放实验室,北京100081

出　　处：《畜牧兽医学报》2024年第5期1926-1935,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：贵州省科技计划项目(黔科中引地[2022]4042);财政部和农业农村部:国家现代农业产业技术体系专项(CARS-38);内蒙古自治区科技重大专项(2021SZD0014)。

摘　　要：后生素是指由对宿主健康有益的无生命的微生物和/或菌体成分/代谢物组成的制剂。有效的后生素,必须包含无生命的微生物细胞或菌体成分,且菌体成分主要包括细胞壁、细胞膜、脂磷壁酸、脂多糖、细胞外囊泡、菌毛和细胞表层蛋白等。本文从后生素调节肠道菌群、增强肠道屏障功能、调节免疫反应、调节机体代谢和调节神经传导等五个方面的益生功能综述其作用机制,并总结了乳杆菌源、酵母源等不同来源的后生素在动物中的应用,以期为后生素后续的分类、开发和利用提供参考。Postbiotics are the preparation of inanimate microorganisms and/or their components/metabolites that confer a health benefit on the host.Effective postbiotics must contain inactivated microbial cells or cell components,and cell components mainly include cell walls,cell membranes,lipoteichoic acid,lipopolysaccharides,extracellular vesicles,pilus and cell surface protein.In this paper,the mechanism of action of postbiotics is reviewed from five aspects of probiotic functions such as regulation of intestinal flora,enhancement of intestinal barrier function,regulation of immune response,regulation of body metabolism and regulation of neurotransmission,etc.,and the application of different sources of postbiotics such as Lactobacillus source and yeast source in animals is also summarised,intending to provide a reference for the subsequent classification,development and utilization of postbiotics.

关 键 词：后生素 作用机制 肠道健康 免疫 动物 

分 类 号：S816.7[农业科学—饲料科学]