武威市凉州区女性人乳头瘤病毒感染与子宫颈病变影响因素分析  

Analysis of influencing factors of human papilloma virus infection and cervical lesions in women in Liangzhou District,Wuwei City

作　　者：林志斌 冯玉霞 蔡萌娜 陈治川 LIN Zhibin;FENG Yuxia;CAI Mengna;CHEN Zhichuan(Department of Obstetrics and Gynecology,Wuwei Liangzhou Hospital,Gansu Province,Wuwei733000,China)

机构地区：[1]甘肃省武威市凉州医院妇产科,甘肃武威733000

出　　处：《中国当代医药》2024年第14期45-48,共4页China Modern Medicine

摘　　要：目的探讨武威市凉州区女性子宫颈人乳头瘤病毒(HPV)感染情况,对子宫颈发生病变与HPV感染行相关性分析。方法采用扩增的聚合酶链式反应(PCR)方法对2021年3月至2023年9月在甘肃省武威市凉州医院进行宫颈癌筛查的13000名妇女进行检查。检测出HPV感染患者有1200例,对其行阴道镜检查及阴道镜下子宫颈活检术。根据宫颈组织活检提示有无子宫颈病变的发生分为两组,分别为病变组(n=486)未病变组(n=714)。运用单因素分析其子宫颈病变发生的影响因素,并运用多因素logistic回归分析方法对单因素中P<0.05中的因素进行分析。结果单因素分析结果提示病变组在年龄、有无持续HPV的感染、子宫颈柱状上皮外移情况、性伴侣数和HPV感染类型上与非病变组具有显著差异,差异有统计学意义(P<0.05);多因素分析结果显示,年龄为<25岁或≥55岁(β=0.754,OR=2.126,95%CI:1.649~2.740)、持续HPV的感染(β=1.048,OR=2.853,95%CI:2.209~3.683)、子宫颈柱状上皮外移(β=0.625,OR=1.868,95%CI:1.453~2.401)、性伴侣数≥2名(β=0.625,OR=1.988,95%CI:1.546~2.556)和HPV感染类型为高危型(β=0.863,OR=2.371,95%CI:1.833~3.066)都是影响子宫颈病变发生的独立危险因素。结论HPV感染与子宫颈病变之间存在联系,且HPV16/HPV18型是子宫颈病变HPV感染的主要类型,倡导定期体检,根据不同女性实施针对性措施对降低女性子宫颈HPV感染发生病变,预防子宫颈癌具深远意义。Objective To explore the prevalence of human papilloma virus(HPV)infection in women in Liangzhou District,Wuwei City,and to conduct a correlation analysis between cervical lesions and HPV infection.Methods The Polymerase Chain Reaction(PCR)method was used to examine 13000 women who underwent cervical cancer screening at Liangzhou Hospital in Wuwei City,Gansu Province,from March 2021 to September 2023.Among the screened individuals,1200 cases were identified with HPV infection,and they underwent colposcopy and cervical biopsy.Based on the presence or absence of cervical lesions according to cervical tissue biopsy results,the patients were divided into two groups:the lesion group(n=486)and the non-lesion group(n=714).Univariate analysis was used to identify factors influencing the occurrence of cervical lesions,and multivariate logistic regression analysis was employed to analyze factors with P<0.05 in the univariate analysis.Results The results of univariate analysis showed significant differences between the lesion and non-lesion groups in terms of age,persistent HPV infection,cervical columnar epithelial displacement,number of sexual partners,and HPV infection type(P<0.05).Multivariate analysis revealed that age<25 or≥55 years(β=0.754,OR=2.126,95%CI:1.649-2.740),persistent HPV infection(β=1.048,OR=2.853,95%CI:2.209-3.683),cervical columnar epithelial displacement(β=0.625,OR=1.868,95%CI:1.453-2.401),number of sexual partners≥2(β=0.625,OR=1.988,95%CI:1.546-2.556)and high-risk HPV infection type(β=0.863,OR=2.371,95%CI:1.833-3.066)were independent risk factors for the occurrence of cervical lesions.Conclusion There is a connection between HPV infection and cervical lesions,with HPV16/HPV18 being the main types of HPV infection associated with cervical lesions.Advocating for regular check-ups and implementing targeted measures for different women are of profound significance for reducing the occurrence of cervical lesions due to HPV infection and preventing cervical cancer.

关 键 词：人乳头瘤病毒感染 人乳头瘤病毒亚型 子宫颈病变 影响因素 

分 类 号：R711[医药卫生—妇产科学]