丽江橐吾全草甲醇提取物的倍半萜类化学成分  

Sesquiterpenoid chemical constituents of methanol extract from the whole plant of Ligularia lidjiangensis

作　　者：马跃 戴伟锋[1] 袁承[1] 张敉[1] MA Yue;DAI Weifeng;YUAN Cheng;ZHANG Mi(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《植物资源与环境学报》2024年第3期107-112,共6页Journal of Plant Resources and Environment

基　　金：国家自然科学基金项目(32060105);云南省应用基础研究面上项目(202301AT070453)。

摘　　要：综合利用多种色谱、波谱和质谱技术从菊科(Asteraceae)橐吾属(Ligularia Cass.)植物丽江橐吾(L.lidjiangensis Hand.-Mazz.)全草甲醇提取物的石油醚部分分离和鉴定出13个艾里莫芬烷型倍半萜,分别为ligularilactone A(1)、6β-hydroxy-8β-methoxyeremophil-7(11)-en-12,8α-olide(2)、8β-hydroxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(3)、8-oxo-eremophil-6-en-11-one(4)、eremophil-7(11),8(9)-dien-12,8(14β,6α)-diolide(5)、8β-methoxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(6)、6β-hydroxyl-7(11)-eremophilen-12,8α-olide(7)、eremophil-8(9)-,7(11)-dien-6α,15;8,12-diolide(8)、6β,8β-dihydroxyeremophi-7(11)-en-12,8α-olide(9)、eremophil-7(11)-ene-12,8α;14β,6α-diolide(10)、2-naphthaleneacetic acid,3,4,4α,5,6,7,8,8α-octahydro-α,8,8α-trimethyl-3-oxo-,methyl ester(11)、(1αR,3αR,7 S,7αR,7βS)-1α-acetyl-7,7α-dimethyloctahydronaphtho[1,2-β]oxiren-2(1αH)-one(12)和6β-hydroxy-8β-methoxyeremophil-7(11)-12,8α-olide(13)。其中,化合物1为新的艾里莫芬烷型倍半萜,化合物2至化合物13则均首次从丽江橐吾中分离得到。Thirteen eremophilane sesquiterpenes were isolated and identified from the petroleum ether fraction of the methanol extract from the whole plant of Ligularia lidjiangensis Hand.-Mazz.,belonging to Ligularia Cass.(Asteraceae),by various chromatography,spectroscopy,and mass spectrometry techniques,viz.ligularilactone A(1),6β-hydroxy-8β-methoxyeremophil-7(11)-en-12,8α-olide(2),8β-hydroxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(3),8-oxo-eremophil-6-en-11-one(4),eremophil-7(11),8(9)-dien-12,8(14β,6α)-diolide(5),8β-methoxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(6),6β-hydroxyl-7(11)-eremophilen-12,8α-olide(7),eremophil-8(9)-,7(11)-dien-6α,15;8,12-diolide(8),6β,8β-dihydroxyeremophi-7(11)-en-12,8α-olide(9),eremophil-7(11)-ene-12,8α;14β,6α-diolide(10),2-naphthaleneacetic acid,3,4,4α,5,6,7,8,8α-octahydro-α,8,8α-trimethyl-3-oxo-,methyl ester(11),(1αR,3αR,7 S,7αR,7βS)-1α-acetyl-7,7α-dimethyloctahydronaphtho[1,2-β]oxiren-2(1αH)-one(12),and 6β-hydroxy-8β-methoxyeremophil-7(11)-12,8α-olide(13).Among them,compound 1 is a new eremophilane sesquiterpene,and compounds 2 to 13 are isolated from L.lidjiangensis for the first time.

关 键 词：丽江橐吾 倍半萜类 分离 鉴定 

分 类 号：Q946.8[生物学—植物学] R284.1[医药卫生—中药学]