Lipid droplets in the nervous system:involvement in cell metabolic homeostasis  

作　　者：Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang 

机构地区：[1]School of Life Sciences,Shanghai University,Shanghai,China [2]School of Medicine,Shanghai University,Shanghai,China [3]Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing,China [4]Center of Excellence in Tissue Engineering,Chinese Academy of Medical Sciences,Beijing,China [5]Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy,Beijing,China

出　　处：《Neural Regeneration Research》2025年第3期740-750,共11页中国神经再生研究（英文版）

基　　金：funded by Basic Research Program of Shanghai,No.20JC1412200(to JW);the National Key Research and Development Program of China,No.2020YFA0113000(to RCZ)。

摘　　要：Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous system.Lipid droplet formation begins with the synthesis of neutral lipids in the endoplasmic reticulum.Previously,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous system.In addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress responses.Furthermore,lipid droplets exhibit specific functions in neurons and glial cells.Dysregulation of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system diseases.This review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and functions.Additionally,it will explore the association between lipid droplets and neurodegenerative disorders.Understanding the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关 键 词：Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease 

分 类 号：R338[医药卫生—人体生理学]