钌催化剂在动态动力学拆分中的应用研究进展  

Research progress on the application of ruthenium catalysts in dynamic kinetic resolution

作　　者：张海 杨敏[1] ZHANG Hai;YANG Min(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,Guizhou,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025

出　　处：《化学研究》2024年第3期244-252,共9页Chemical Research

基　　金：国家自然科学基金项目(21562014);贵州中烟工业有限公司资助项目(Z164004)。

摘　　要：手性化合物在有机合成中具有重要的作用,广泛应用于医药、农业、食品和材料等领域。获得单一手性化合物的方法一直是重要的研究课题,但是,一般的合成或提取方法得到的多是外消旋体。动态动力学拆分为外消旋体完全转化成单一对映体提供了一种强大的方法,该方法可以将一种构型的对映异构体选择性拆分,同时另一种构型的对映异构体外消旋化,从而获得单一构型的产物,且对映体过量值可达到>99%,理论产率可达到100%。研究者已经开发了一些钌-酶催化体系、钌-非酶催化体系和钌-手性配体络合物用于烯丙醇、二醇、含官能团的仲醇的动态动力学拆分,以及酮和酯的不对称转移氢化动态动力学拆分的有效方法。本文将对这些方法进行综述,并提供相关的示例,以期为这些方法的更进一步应用提供参考。Chiral compounds play an important role in organic synthesis and are widely used in the fields of medicine,agriculture,food,and materials.Methods for obtaining single chiral compound have always been an important research topic,however,the general synthesis or extraction methods often obtain racemates.Dynamic kinetic resolution provides a powerful methodology for the complete transformation of racemates into single enantiomers.In dynamic kinetic resolution,one enantiomer is selectively converted to the product with the simultaneous racemization of the other enantiomer,thus affording a high yield approaching 100%with an enantiomeric excess value of>99%.Several groups have explored a series of ruthenium-enzymatic catalytic systems,ruthenium-non-enzymatic catalytic systems,and ruthenium-chiral ligand complexes for dynamic kinetic resolutions of allyl alcohols,diols,and functionalized secondary alcohols,as well as the asymmetric transfer hydrogenation of ketones and esters.This paper provides a review of these dynamic kinetic resolution procedures with detailed examples for each of them to provide a reference for the further application of these methods.

关 键 词：钌催化剂 钌-酶催化体系 钌-非酶催化体系 动态动力学拆分 

分 类 号：O62[理学—有机化学]