罗库溴铵与苯磺顺阿曲库铵对结直肠癌根治术肌松效果及应激反应的影响  

Effects of rocuronium and cisatracurium besilate on muscle relaxation and stress response in patients undergoing radical resection of colorectal cancer

作　　者：赵贤姬 ZHAO Xian-ji(Department of Anesthesiology,Beijing Luhe Hospital,Capital Medical University,Beijing 101199,China)

机构地区：[1]首都医科大学附属北京潞河医院麻醉科,北京101199

出　　处：《川北医学院学报》2024年第5期700-703,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨罗库溴铵与苯磺顺阿曲库铵对结直肠癌根治术患者肌松效果及应激反应的影响。方法:将110例行腹腔镜结直肠癌根治术患者按照麻醉方式不同分为观察组和对照组,每组各55例。对照组麻醉期间肌松药物为苯磺顺阿曲库铵;观察组麻醉期间肌松药物为罗库溴铵。比较两组肌松效果、临床指标及不良反应发生情况。结果:观察组肌松效果高于对照组(P<0.05),观察组四个成串刺激(TOF)起效时间短于对照组(P<0.05),平均动脉压与心率均低于对照组(P<0.05),观察组肌松药物维持时间长于对照组(P<0.05);两组患者麻醉诱导前(T0)时应激反应指标差异无统计学意义(P>0.05);手术开始时(T1)、手术30 min后(T2)及手术结束后30 min(T3)时,观察组肾上腺素、去甲肾上腺素水平均低于对照组(P<0.05);两组TOF恢复25%时间、TOF恢复75%时间及不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:罗库溴铵在结直肠癌根治术中肌松效果更佳,应激反应与不良反应发生风险相对更小。Objective:To investigate the effects of rocuronium and cisatracurium besilate on muscle relaxation and stress response in patients undergoing radical resection of colorectal cancer.Methods:110 patients undergoing laparoscopic radical resection of colorectal cancer were divided into observation group and control group according to different anesthesia methods,with 55 cases in each group.Cisatracurium besilate was used as neuromuscular relaxant in control group during anesthesia,while rocuronium bromide was used as neuromuscular relaxant in observation group during anesthesia.The neuromuscular blockade effect,clinical indicators and the incidence of adverse reactions were compared between the two groups.Results:The effect of NMB in the observation group was higher than that in the control group(P<0.05).The onset time of train-of-four ratio(TOF)in the observation group was shorter than that in the control group(P<0.05).The average arterial pressure and heart rate were lower than those in the control group(P<0.05).The duration of NMB in the observation group was longer than that in the control group(P<0.05).There were no significant differences in the stress response indexes between the two groups at before anesthesia induction(T0)(P>0.05).The levels of epinephrine and norepinephrine in the observation group were lower than those in the control group at the beginning of surgery(T1),30 minutes after surgery(T2),and 30 minutes after surgery(T3)(P<0.05).There was no statistically significant difference in the recovery time of 25%and 75%of TOF,as well as the incidence of adverse reactions,between the two groups(P>0.05).Conclusion:Rocuronium is more effective in muscle relaxation during radical resection of colorectal cancer,and the risk of stress reaction and adverse reaction is relatively small.

关 键 词：结直肠癌 罗库溴铵 苯磺顺阿曲库铵 肌松效果 应激反应 

分 类 号：R614.2[医药卫生—麻醉学] R735.3[医药卫生—外科学]