Corrosion and in vitro cytocompatibility investigation on the designed Mg-Zn-Ag metallic glasses for biomedical application  

作　　者：Jian Wang Lingzhong Meng Weixin Xie Chen Ji Ronghua Wang Pinghu Zhang Liling Jin Liyuan Sheng Yufeng Zheng 

机构地区：[1]School of Mechanical Engineering,Yangzhou University,Yangzhou,225127,China [2]Department of Materials Science and Engineering,Seoul National University,Seoul,South Korea [3]Huizhou Port Customs,Huizhou,516081,China [4]Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases,Institute of Translational Medicine,Medical College,Yangzhou University,Yangzhou,225009,China [5]Center for Research in Computational Thermochemistry(CRCT),Department of Chemical Engineering,Ecole polytechnique de Montréal,Montréal,Québec,H3C 3A7,Canada [6]Shenzhen Institute,Peking University,Shenzhen 518057,China [7]PKU-HKUST ShenZhen-HongKong Institution,Shenzhen,518057,China

出　　处：《Journal of Magnesium and Alloys》2024年第4期1566-1580,共15页镁合金学报（英文）

基　　金：National Key Research and Development Program of China(2018YFC1106702);Guangdong Basic and Applied Basic Research Foundation(2020A1515011301,2019A1515110067 and 2020A1515110055);Shenzhen Basic Research Project(JCYJ20210324120001003,JCYJ20200109144608205 and JCYJ20200109144604020);IER Foundation(HT-JDCXY-201902 and HT-JD-CXY-201907)for financial support.

摘　　要：In the present work,seven Mg-Zn-Ag alloys with the nominal composition of Mg_(96-x)Zn_(x)Ag_(4)(x=17,20,23,26,29,32,35 in at.%)were prepared by induction melting and single-roller melt-spinning.The X-ray diffraction(XRD)analyses indicate the metallic glasses with three composition of Mg_(73)Zn_(23)Ag_(4),Mg_(70)Zn_(26)Ag_(4),and Mg_(67)Zn_(29)Ag_(4)were obtained successfully.The differential scanning calorimetry(DSC)measurement was used to obtain the characteristic temperature of Mg-Zn-Ag metallic glasses for the glass-forming ability analysis.The maximum glass transition temperature(Trg)was found to be 0.525 with a composition close to Mg_(67)Zn_(29)Ag_(4),which results in the best glass-forming ability.Moreover,the immersion test in simulated body fluid(SBF)demonstrate the relative homogeneous corrosion behavior of the Mg-Zn-Ag metallic glasses.The corrosion rate of Mg-Zn-Ag metallic glasses in SBF solution decreases with the increase of Zn content.The sample Mg_(67)Zn_(29)Ag_(4)has the lowest corrosion rate of 0.19mm/yr,which could meet the clinical application requirement well.The in vitro cell experiments show that the Madin-Darby canine kidney(MDCK)cells cultured in sample Mg_(67)Zn_(29)Ag_(4)and its extraction medium have higher activity.However,the Mg-Zn-Ag metallic glasses exhibit obvious inhibitory effect on human rhabdomyosarcoma(RD)tumor cells.The present investigations on the glass-forming ability,corrosion behavior,cytocompatibility and tumor inhibition function of the Mg-Zn-Ag based metallic glass could reveal their biomedical application possibility.

关 键 词：Metallic glasses Mg-Zn-Ag Corrosion behavior In vitro cytocompatibility 

分 类 号：R318.08[医药卫生—生物医学工程] TG146.22[医药卫生—基础医学]