人参皂苷CK美容护肤作用及机制研究进展  

Research Advances on Beauty and Skin Care Effect and Mechanismof Ginsenoside CK

作　　者：叶萍 张慧娥 初孟瑶 侯剑峰 周蕖 魏琨 陈长宝 李光[4] 王恩鹏 YE Ping;ZHANG Huier;CHU Mengyao;HOU Jianfeng;ZHOU Qu;WEI Kun;CHEN Changbao;LI Guang;WANG Enpeng(Changchun University of Chinese Medicine,Jilin Provincial Institute of Ginseng Science,Changchun 130117,China;Shiqi Biological Research and Development Center(Suzhou Industrial Park)Co.,Ltd.,Suzhou 215125,China;Jilin Zixin Pharmaceutical Co.,Ltd.,Changchun 135300,China;The First Affiliated Hospital of Changchun University of Tra-ditional Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学,吉林省人参科学研究院,吉林长春130117 [2]士齐生物研发中心(苏州工业园区)有限公司,江苏苏州215125 [3]吉林紫鑫药业股份有限公司,吉林长春135300 [4]长春中医药大学附属第一医院,吉林长春130117

出　　处：《特产研究》2024年第3期161-167,共7页Special Wild Economic Animal and Plant Research

基　　金：吉林省科技发展计划项目(20210401108YY、20200404042YY);长春市科技局重点研发计划项目(21ZGY10);珈伊生化研发中心(苏州工业园区)有限公司项目(20191120)。

摘　　要：人参(Panax ginseng C.A.Mey.)具有重要的药用和保健价值,在我国已有几千年的应用历史,尤其在美容护肤方面的应用非常盛行。目前,人参已成为化妆品原料中非常重要的抗衰老、美白和嫩肤的成分之一。近年来,在一些国内和国际化妆品品牌产品中被广泛应用。本文总结人参中的20(S)原人参二醇-20-O-β-D-吡喃葡萄糖苷(Compound K,CK)这一成分在皮肤方面的应用,并综述了CK在美容护肤方面的作用及机制。CK是一种由二醇型人参皂苷生物转化而来的脱糖代谢物,比其母体人参皂苷具有更高的生物利用度及溶解性,更容易被人体吸收,近年来备受关注。研究发现,CK具有光保护、抗衰老、保湿和抗炎等多种美容护肤方面的作用。目前的研究主要集中于CK在抗癌中的应用机制,然而,在皮肤美容护肤方面的研究相对较少。本文总结了CK在护肤方面的作用,并重点阐释了CK护肤的分子机制,如抗紫外线辐射机制、抗衰老和保湿机制以及抗炎机制,可为今后CK在美容护肤领域中更深层次的研究及开发提供参考。Ginseng(Panax ginseng C.A.Mey.)has been widely used in China for thousands of years because of its superior medicinal and health care value,especially in beauty and skin care.At present,it has become one of the most important anti-aging,whitening and skin-rejuvenating ingredients in cosmetic raw materials in China and even in the world,and has been widely used in some international cosmetic brands in recent years.To explore the application of 20(S)protopanaxadiol-20 murine O--D-glucopyranoside(Compound K,CK)in ginseng in recent years,the function and mechanismof CKin cosmetology and skin care in recent years were reviewed.CKhas attracted much attention because it is a deglycemic metabolite derived fromdiol ginsenosides,which has higher bioavailability and solubility than its parent ginsenosides,and is easier to be absorbed by human body.It is found that CK has many functions of beauty and skin care,such as light protection,anti-aging,moisturizing,anti-inflammation and so on.At present the research mainly focuses on the application mechanismof CK in ant-cancer,however,there are relatively few researches on skin beauty and care.This study summarizes the funtion of CK in skin care,and focuses on the molecular mechanismof CKskin care.This paper intends to provide a reference basis for the further research and development of CK in the field of beauty and skin care in the future.

关 键 词：人参皂苷CK 光保护 抗衰老 护肤机制 研究进展 

分 类 号：R285[医药卫生—中药学]