大隐静脉高位结扎联合泡沫硬化剂注射术+外用重组人酸性成纤维细胞生长因子治疗重度静脉曲张合并溃疡患者的临床疗效  

Clinical effect of high ligation of great saphenous vein combined with foam sclerosing agent injection+recombinant human acidic fibroblast growth factor for external use in the treatment of severe varicose veins complicated with ulcer

作　　者：江榕[1,2,3] 何洪青 陈小彬 林晨 王瑜[1,3] Jiang Rong;He Hongqing;Chen Xiaobin;Lin Chen;Wang Yu(Clinical Medical College of Fuzhou General Hospital of Fujian Medical University,Fuzhou 350025,Fujian,China;Graduate School of Fujian Medical University,Fuzhou 350025,Fujian,China;Department of General Surgery,the 900th Hospital of China People's Liberation Army Joint Logistics Support Force,Fuzhou 350025,Fujian,China;Department of Burn and Plastic Surgery,the 900th Hospital of China People's Liberation Army Joint Logistics Support Force,Fuzhou 350025,Fujian,China)

机构地区：[1]福建医科大学福州总医院临床医学院,福建福州350025 [2]福建医科大学研究生院,福建福州350025 [3]解放军联勤保障部队第九〇〇医院普通外科,福建福州350025 [4]解放军联勤保障部队第九〇〇医院烧伤整形科,福建福州350025

出　　处：《血管与腔内血管外科杂志》2024年第3期257-261,281,共6页Journal of Vascular and Endovascular Surgery

基　　金：联勤保障部队第九〇〇医院训练伤防治专项(2023XL02);联勤医学重点学科(LQZD-PW)。

摘　　要：目的探讨大隐静脉高位结扎联合泡沫硬化剂注射术+外用重组人酸性成纤维细胞生长因子治疗重度静脉曲张合并溃疡患者的临床疗效。方法收集2018年1月至2023年6月解放军联勤保障部队第九〇〇医院收治的60例大隐静脉曲张患者的临床资料,按照治疗方式的不同将其分为对照组(n=30)与观察组(n=30),两组患者均采用大隐静脉高位结扎联合泡沫硬化剂注射术,对照组溃疡创面采用碘伏和生理盐水常规换药,观察组溃疡创面采用外用重组人酸性成纤维细胞生长因子治疗。比较两组患者手术时间、术中出血量、住院时间、住院费用、术后并发症的发生情况、治疗前后溃疡面积、溃疡愈合时间、疼痛数字评价量表(NRS)评分以及患者对诊疗过程的满意度。结果观察组患者住院时间短于对照组患者,差异有统计学意义(P﹤0.05)。术后第7天,两组患者溃疡面积均小于本组术前,且观察组患者溃疡面积小于对照组患者,差异均有统计学意义(P﹤0.05)。观察组患者溃疡愈合时间短于对照组患者,差异有统计学意义(P﹤0.05)。术后第14天,两组患者NRS评分均低于本组术前,且观察组患者NRS评分低于对照组患者,差异均有统计学意义(P﹤0.05)。观察组患者满意度评分高于对照组患者,差异有统计学意义(P﹤0.05)。结论大隐静脉高位结扎联合泡沫硬化剂注射术+外用重组人酸性成纤维细胞生长因子可显著促进下肢静脉性溃疡创面的愈合,明显缩短溃疡愈合时间、住院时间,缓解患者下肢疼痛程度,提高患者的诊疗满意度,值得在临床上进一步推广应用。Objective To analyze the clinical efficacy of high ligation of great saphenous vein combined with foam sclerosing agent injection and recombinant human acidic fibroblast growth factor for external use in the treatment of patients with severe varicose veins complicated with ulcer.Method Clinical data of 60 patients with varicose great saphenous vein admitted to the 900th Hospital of China People's Liberation Army Joint Logistics Support Force from January 2018 to June 2023 were collected.According to different treatment methods,they were divided into control group(n=30)and the observation group(n=30),high ligation of great saphenous vein and injection of foam sclerosing agent were used in both groups,the control group ulcer wound was treated with iodine and physiological saline for routine dressing changes,while the observation group ulcer wound was treated with topical recombinant human acidic fibroblast growth factor.Operation time,intraoperative blood loss,hospital stay,hospital cost,postoperative complications,ulcer area before and after treatment,ulcer healing time,numerical rating scale(NRS)and patients'satisfaction with diagnosis and treatment were compared between the two groups.Result The hospitalization time of observation group was shorter than that of control group,the differences were statistically significant(P<0.05).On the 7th day after surgery,the ulcer area of both groups was smaller than that before surgery,the ulcer area of observation group was smaller than that of control group,the differences were statistically significant(P<0.05).The ulcer healing time of observation group was shorter than that of control group,the difference was statistically significant(P<0.05).On the 14th day after surgery,NRS score in both groups was lower than that before surgery,and NRS score in observation group was lower than that in control group,the differences were statistically significant(P<0.05).The satisfaction score of the observation group was higher than that of the control group,the difference was statisti

关 键 词：大隐静脉曲张 溃疡 泡沫硬化剂注射术 外用重组人酸性成纤维细胞生长因子 高位结扎 

分 类 号：R543[医药卫生—心血管疾病]