Molecular cascades and cell type-specific signatures in ASD revealed by single-cell genomics  

作　　者：Brie Wamsley 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2024年第5期993-993,共1页Sichuan Journal of Physiological Sciences

摘　　要：Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes.What drives these changes and how they relate to genetic susceptibility in this complex condition are not well understood.We performed deep single-nucleus RNA sequencing(snRNA-seq)to examine cell composition and transcriptomics,identifying dysregulation of cell type-specific gene regulatory networks(GRNs)in autism spectrum disorder(ASD).

关 键 词：signature ASD MOLECULAR 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]