负压伤口疗法预防肝癌切除术后患者切口感染的效果及其对切口愈合质量及血清炎性因子的影响  

Effect of negative pressure wound therapy on the prevention of wound infection in patients with hepatocellular carcinoma after resection and its effect on wound healing quality and serum inflammatory factors

作　　者：李会转[1] 曹爱梅 张卫卫[1] Li Hui-zhuan;Cao Ai-mei;Zhang Wei-wei(Department of Hepatobiliary Pancreaticosplenic Hernia,Luoyang Central Hospital,Luoyang 471000,Henan,China)

机构地区：[1]洛阳市中心医院肝胆胰脾疝外科,河南洛阳471000

出　　处：《四川生理科学杂志》2024年第5期1042-1044,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨负压伤口疗法(Negative-pressure wound therapy,NPWT)预防肝癌切除术后患者切口感染的效果及其对切口愈合质量及血清炎性因子的影响。方法:选取2020年1月至2022年12月期间我院收治的80例肝癌切除术后患者作为研究对象,按照随机数字表法分为对照组和观察组,各40例。对照组患者在术后接受常规伤口疗法,观察组在术后接受NPWT。观察两组患者康复情况、术后切口恢复效果、炎性因子、术后并发症。结果:观察组患者拆线时间及住院治疗时间均明显短于对照组患者(P<0.05);观察组患者创面新鲜肉芽组织生长时间及切口愈合时间均明显短于对照组(P<0.05);治疗后观察组患者炎性因子水平瘤坏死因子-α(Tumour necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)均明显低于对照组(P<0.05);观察组术后并发症发生率明显低于对照组(P<0.05)。结论:对肝癌切除术后患者采用负压伤口疗法可缩短患者拆线及住院时间,促进患者术后恢复,改善炎症水平、减少切口感染等并发症。Objective:To investigate the effect of Negative-pressure wound therapy(NPWT)on the prevention of wound infection after hepatocellular carcinoma resection and its effect on the quality of wound healing and serum inflammatory factors.Methods:A total of 80 patients with hepatocellular carcinoma treated in our hospital from January 2020 to December 2022 were selected as research objects and divided into control group and observation group according to random number table method,with 40 cases in each group.The control group received conventional wound therapy and the observation group received NPWT.The recovery,incision recovery effect,inflammatory factors and postoperative complications were observed in the two groups.Results:The duration of suture removal and hospitalization in observation group were significantly shorter than those in control group(P<0.05).The growth time of fresh granulation tissue and incision healing time in observation group were significantly shorter than those in control group(P<0.05).The levels of inflammatory factors in the Tumor necrosis factor-α(TNF-α),Interleukin-6(IL-6)and C-reactive protein(CRP)in the observation group after treatment was significantly lower than that of control group(P<0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:The use of negative pressure wound therapy for patients after hepatocellular carcinoma resection can shorten the duration of suture removal and hospitalization,promote postoperative recovery,improve the level of inflammation and reduce the complications of incision infection.

关 键 词：负压伤口疗法 肝癌 炎症水平 切口感染 

分 类 号：R473.73[医药卫生—护理学]