CXCL4与非ST段抬高心肌梗死患者冠状动脉病变稳定性的相关性研究  

Correlation between CXCL4 and the stability of coronary artery lesions in patients with non-ST segment elevation myocardial infarction

作　　者：苏伟锋 Su Wei-feng(Cardiology Ward 1,Xinzheng Huaxin People's Hospital,Zhengzhou 451100,China)

机构地区：[1]新郑华信民生医院心血管一病区,河南郑州451100

出　　处：《四川生理科学杂志》2024年第5期1077-1079,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨血清血小板趋化因子4(CXC chemokine ligand 4,CXCL4)水平与非ST段抬高心肌梗死患者冠状动脉病变稳定性的相关性。方法:选取2021年1月至2022年12月期间于本院接受治疗的90例非ST段抬高心肌梗死伴冠状动脉病变患者作为研究对象,采用冠脉造影检查冠状动脉病变稳定性,并根据冠脉造影检查结果,将患者分为稳定组和不稳定组(n=45)。所有入选者均采用酶联免疫吸附法测定血清CXCL4水平,分析血清CXCL4水平与非ST段抬高心肌梗死患者冠状动脉病变稳定性的关系。结果:稳定组血清CXCL4水平显著低于不稳定组(P<0.05)。建立Logistic回归分析模型,结果显示,血清CXCL4水平高与非ST段抬高心肌梗死患者发生不稳定性冠状动脉病变密切相关(OR>1,P<0.05)。绘制受试者工作特征(Receiver operator characteristic,ROC)曲线结果显示,血清CXCL4水平预测不稳定型冠状动脉病变的曲线下面积>0.8,具有一定预测价值。结论:非ST段抬高心肌梗死患者血清CXCL4水平与冠状动脉病变稳定性密切相关,在冠状动脉病变稳定性预测中具有较高价值。Objective:To investigate the correlation between serum platelet chemokine ligand 4(CXC chemokine ligand 4,CXCL4)levels and the stability of coronary artery disease in patients with non-ST segment elevation myocardial infarction.Methods:90 patients with non-ST elevation myocardial infarction with coronary artery disease who received treatment in our hospital from January 2021 to December 2022 were selected as the study objects.The stability of coronary artery disease was examined by coronary angiography.According to the results of coronary angiography,the patients were divided into stable group and unstable group(n=45).Serum CXCL4 levels were measured by enzyme-linked immunosorbent assay(ELISA),and the relationship between serum CXCL4 levels and the stability of coronary artery disease in patients with non-ST elevation myocardial infarction was analyzed.Results:The serum CXCL4 level in stable group was significantly lower than that in unstable group(P<0.05).Logistic regression analysis model was established,and the results showed that the high level of serum CXCL4 was closely related to the occurrence of unstable coronary artery lesions in patients with non-ST segment elevation myocardial infarction(OR>1,P<0.05).The results of Receiver operator characteristic(ROC)curve showed that the area under the curve of serum CXCL4 level in predicting unstable coronary artery lesions was>0.8,which had certain predictive value.Conclusion:The serum CXCL4 level in patients with non-ST segment elevation myocardial infarction is closely related to the stability of coronary artery disease,and has a high value in predicting the stability of coronary artery disease.

关 键 词：心肌梗死 非ST段抬高 血小板趋化因子4 冠状动脉病变稳定性 

分 类 号：R542.22[医药卫生—心血管疾病]