纤维支气管镜下肺泡灌洗对MP感染致大叶性肺炎患儿炎性因子水平及免疫功能的影响  

Effect of alveolar lavage under fiberbronchoscope on inflammatory factors and immune function in children with lobar pneumonia caused by MP infection

作　　者：李德升[1] 袁春丽 王景涛 Li De-sheng;Yuan Chun-li;Wang Jing-tao(Department of Pediatrics,Suixian Maternal and Child Health Hospital,Shangqiu 476900,Henan,China)

机构地区：[1]睢县妇幼保健院儿科,河南商丘476900

出　　处：《四川生理科学杂志》2024年第5期1135-1137,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:分析纤维支气管镜下肺泡灌洗对肺炎支原体(Mycoplasma pneumoniae,MP)感染致大叶性肺炎(Lobar pneumonia,LP)患儿的影响。方法:选取2021年4月~2023年4月本院收治的92例MP感染致LP患儿作为研究对象,随机分为对照组和研究组,各46例。对照组患者静脉滴注乳糖酸红霉素和阿奇霉素治疗,研究组在对照组基础上加用纤维支气管镜下肺泡灌洗治疗。分析比较两组的临床疗效、肺功能、病情严重程度、炎性因子以及免疫功能。结果:治疗后,研究组总有效率、用力肺活量(Forced vital capacity,FVC)、最高呼气流量(Peak expiratory flow,PEF)、CD3+、CD4+、CD4+/CD8+均明显高于对照组(P<0.05);研究组临床肺部感染评分(Clinicalpulmonary infectionscore,CPIS)、血清C反应蛋白(C-reactiveprotein,CRP)、降钙素原(Procalcitonin,PCT)、烟酰胺磷酸核糖转移酶(Nicotinamide phosphoribosyl transferase,NAMPT)水平均明显低于对照组(P<0.05)。结论:纤维支气管镜下肺泡灌洗治疗MP感染致LP患儿,能提高临床疗效,改善肺功能、免疫功能,减轻炎性反应。Objective:To investigate the effect of bronchoscopic alveolar lavage on Lobar pneumonia(LP)in children with Mycoplasma pneumoniae(MP)infection.Methods:A total of 92 children with LP caused by MP infection admitted to our hospital from April 2021 to April 2023 were selected as research objects and randomLy divided into control group and study group,46 cases in each group.The control group was treated with intravenous infusion of erythromycin lactonate and azithromycin,and the study group was treated with alveolar lavage under fiberoptic bronchoscope on the basis of control group.The clinical efficacy,lung function,severity of disease,inflammatory factors and immune function of the two groups were analyzed and compared.Results:After treatment,the total effective rate,Forced vital capacity(FVC),Peak expiratory flow(PEF),CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the study group were significantly higher than those in the control group(P<0.05).Clinical pulmonary infection score(CPIS),serum C-reactive protein(CRP),Procalcitonin(PCT),and Nicotinamide phosphoribosyl transferase(NAMPT)were significantly lower than those of control group(P<0.05).Conclusion:Fiberbronchoscopic alveolar lavage can improve the clinical efficacy,lung function,immune function and inflammatory response in LP children with MP infection.

关 键 词：纤维支气管镜下肺泡灌洗 肺炎支原体 大叶性肺炎 炎性因子 免疫功能 

分 类 号：R725.6[医药卫生—儿科]