脾虚证实验动物模型构建及评价方法的研究述评  

Construction of experimental animal models and evaluation of spleen deficiency syndrome:a review

作　　者：张永龙 马唯刚 钱星羽 赵素红 李姗姗[1] 郭永明[1,2] 徐枝芳 潘兴芳 邱继文[1,3] 郭义 李忠正 ZHANG Yonglong;MA Weigang;QIAN Xingyu;ZHAO Suhong;LI Shanshan;GUO Yongming;XU Zhifang;PAN Xingfang;QIU Jiwen;GUO Yi;LI Zhongzheng(Experimental Acupuncture Research Center,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Acupuncture and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Medical Technology,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学实验针灸学研究中心,天津301617 [2]天津中医药大学针灸推拿学院,天津301617 [3]天津中医药大学医学技术学院,天津301617 [4]天津中医药大学,天津301617

出　　处：《中国实验动物学报》2024年第3期385-396,共12页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金面上项目(82174524)。

摘　　要：中医症候实验动物模型的构建在中医药作用机理研究方面起到重要支撑作用,近年来脾虚证动物模型的构建和评价文献报道越来越多,但是构建方法标准不一,评价指标客观化不足,本文将从动物选取、模型建立、宏观表征、行为学实验、脾虚的客观指标等方面总结脾虚动物模型的构建和评价方法,以期为脾虚证实验动物模型的构建提供理论指导,为脾虚动物模型平台的选取提供文献参考。The construction of experimental animal models plays an important supporting role in research into the mechanisms of action of Chinese medicines.There have been increasing reports of the construction and evaluation of animal models of spleen deficiency;however,the construction method have involved different standards and there has been insufficient objectification of the evaluation indexes.In this review,we summarize the construction and evaluation method of animal models of spleen deficiency from the aspects of animal selection,model establishment,macroscopic characterization,behavioral experiments,and objective indexes of spleen deficiency,with a view to providing theoretical guidance for the construction of experimental animal models of spleen deficiency and references for the selection of animal model platforms for spleen deficiency.

关 键 词：脾虚证 动物模型 评价方法 综述 

分 类 号：Q95-33[生物学—动物学]