针刺内关穴防治晕动病的实验研究  

Experimental study on the prevention and treatment of motion sickness by acupuncture at Neiguan

作　　者：方晶晶 姜雨佳 孙超越 蔡孟成 尤艳利 Fang Jingjing;Jiang Yujia;Sun Chaoyue;Cai Mengcheng;You Yanli(No.2 Student Team,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学学员二队,上海200433 [2]海军军医大学学员一队,上海200433 [3]海军军医大学中医系,上海200433

出　　处：《海军医学杂志》2024年第4期366-370,共5页Journal of Navy Medicine

基　　金：海军军医大学三航两海人才计划项目;军委后勤保障部卫生局中医药服务能力培育与提升专项计划项目(2021ZY012);后勤科研重点项目(BHJ22J021)。

摘　　要：目的探讨针刺内关穴、针刺上肢和传统药物治疗防治晕动病的效果。方法将30只雄性KM小鼠按随机数字表法分为空白对照组、模型组(加速度暴露)、针刺穴位组(针刺内关穴+加速度暴露)、针刺上肢组(针刺上肢非内关穴的位置+加速度暴露)和传统药物组(眩晕宁灌胃+加速度暴露)5组,每组6只。检测各组小鼠晕反应指数、血清5-羟色胺、肾上腺素、胰高血糖素、胰岛素及血糖水平。结果与空白对照组比较,模型组晕反应指数、血清5-羟色胺、肾上腺素、胰高血糖素、胰岛素及血糖水平均升高(P<0.05);与模型组比较,针刺穴位组与传统药物组晕反应指数、血清5-羟色胺、肾上腺素、胰高血糖素及血糖水平均降低(P<0.05),胰岛素水平差异无统计学意义(P>0.05);传统药物组肾上腺素含量较针刺穴位组更低(P<0.05);针刺上肢组晕反应指数低于模型组,胰岛素水平高于模型组,差异均有统计学意义(P<0.05),而血清5-羟色胺、肾上腺素、胰高血糖素及血糖水平差异无统计学意义(P>0.05)。结论眩晕宁与针刺内关穴均能有效缓解晕动病的严重程度。Objective To compare the therapeutic effect of acupuncture at Neiguan point(PC6),acupuncture on the upper limbs and traditional medication for motion sickness.Methods Totally 30 male KM mice were randomly divided into 5 groups(n=6):blank control group,model group(acceleration exposure),acupuncture PC6 group(acupuncture at PC6+acceleration exposure),acupuncture upper limbs group(acupuncture of the arm except PC6+acceleration exposure)and traditional medicine group(difenidol administered intragastrically+acceleration exposure).The motion sickness index(MSI)and the serum levels of serotonin(5‑HT),adrenaline,glucagon,insulin and blood glucose were detected.Results MSI and serum 5‑HT,adrenaline,glucagon,insulin and blood glucose levels in the model group were significantly higher than those in the blank control group(P<0.05).Compared with those in the model group,MSI and 5‑HT,adrenaline,glucagon and blood glucose levels were decreased in the acupuncture PC6 group and traditional medicine group(P<0.05),while insulin level was not significantly changed(P>0.05).The adrenaline level in the traditional medicine group was lower than that in the acupuncture PC6 group(P<0.05).The acupuncture upper limbs group had lower MSI and higher insulin level than the model group(P<0.05),while there were no significant differences in the levels of 5‑HT,adrenaline,glucagon or blood glucose between the two groups(P>0.05).Conclusion Both difenidol and acupuncture at PC6 can effectively relieve motion sickness.

关 键 词：晕动病 针刺 内关穴 小鼠 

分 类 号：R339.174[医药卫生—人体生理学] R835.1[医药卫生—基础医学]