双链蛋白聚糖Biglycan在骨退行性疾病中的作用机制研究进展  

Research progress on the mechanism of action of Biglycan in bone degenerative diseases

作　　者：符永华 李吉 王裕倩 邓小中 崔红旺 FU Yonghua;LI Ji;WANG Yuqian;DENG Xiaozhong;CUI Hongwang(Trauma Medicine Center,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China;Clinical College,Hainan Medical University,Haikou 571199,China.)

机构地区：[1]海南医学院第一附属医院创伤医学中心,海南海口570102 [2]海南医学院临床学院,海南海口571199

出　　处：《海南医学院学报》2024年第10期790-794,共5页Journal of Hainan Medical University

基　　金：海南省重点研发项目(ZDYF2021SHFZ084)。

摘　　要：Biglycan是最近发现的一种富含亮氨酸的双链蛋白聚糖,广泛存在于各类结缔组织当中,在许多器官和系统中具有关键作用,通过参与细胞的生长、凋亡的全过程,进而导致多种疾病的发生和发展。近年来,随着研究不断的深入,Biglycan被证实可通过调控细胞外基质的表达、抑制成骨细胞的分化和促进破骨细胞前体细胞的活化等方面导致骨退行性疾病的发生发展。本文通过对Biglycan在骨退行性疾病(骨质疏松症、骨关节炎、椎间盘退行性病变)中扮演的角色进行阐述,旨在为临床诊疗活动提供新的思路。Biglycan is a recently discovered small leucine-rich proteoglycan,widely found in various connective tissues.It has a key role in many organs and systems,and leads to the occurrence and development of a variety of diseases by participating in the whole process of cell growth and apoptosis.In recent years,with the deepening of research,Biglycan has been confirmed to lead to the occurrence and development of bone degenerative diseases by regulating the expression of extracellular matrix,inhibiting the differentiation of osteoblasts and promoting the activation of osteoclast precursor cells.This article aims to provide new ideas for clinical diagnosis and treatment activities by elaborating the role of Biglycan in bone degenerative diseases(Osteoporosis,Osteoarthritis,and Intervertebral disc degeneration).

关 键 词：BIGLYCAN 骨质疏松症 骨关节炎 椎间盘退行性病变 

分 类 号：R68[医药卫生—骨科学]