从气虚血瘀探讨铁死亡与椎动脉型颈椎病的关系  

Discussion on relationship between ferroptosis and cervical spondylosis of vertebral artery type based on qi deficiency and blood stasis

作　　者：王凯 宋永嘉 宋敏 WANG Kai;SONG Yongjia;SONG Min(Department of Orthopedics,Gansu Provincial Hospital,Lanzhou,Gansu 730000,China;Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃省人民医院骨科,甘肃兰州730000 [2]甘肃中医药大学中医临床学院,甘肃兰州730000

出　　处：《上海中医药杂志》2024年第6期40-43,52,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81760876);甘肃省自然科学基金项目(1610RJZA069);甘肃省教育厅优秀研究生“创新之星”项目(2021CXZX-765);甘肃省教育厅高等学校科学研究项目(2017A-053)。

摘　　要：从气虚血瘀探讨铁死亡与椎动脉型颈椎病(CSA)的关系。椎动脉遭受刺激、压迫后的缺血、缺氧状态是CSA发生的病理基础。中医认为CSA的关键病机是气虚血瘀,气虚推动无力,瘀血内停,血液流变学指标改变,病理产物积聚,容易触发血管内皮细胞铁死亡,加重病情进展。从气虚血瘀病机与铁死亡理论探讨CSA的中医药防治,为CSA的临床诊治提供新思路。Discussion on the relationship between ferroptosis and cervical spondylosis of vertebral artery type(CSA)based on qi deficiency and blood stasis.The ischemic and hypoxic state of vertebral artery after stimulation and compression are the pathological basis of CSA.Qi deficiency and blood stasis are the key pathogenesis of CSA in traditional Chinese medicine.Qi deficiency promoting weakness,blood stasis,hemorheology index changes,and accumulation of pathological products,which can easily triggers ferroptosis in vascular endothelial cells and further aggravates the progression of the disease.The prevention and treatment of CSA by traditional Chinese medicine based on the pathogenesis of qi deficiency and blood stasis and the theory of ferroptosis are explored,in order to provide the new ideas for the clinical diagnosis and treatment of CSA.

关 键 词：椎动脉型颈椎病 气虚血瘀 血管内皮细胞 铁死亡 血管微环境 中医理论 作用机制 

分 类 号：R274.9[医药卫生—中西医结合]