杏仁核对焦虑样睡眠障碍的调控  

Role of amygdala in the regulation of anxiety-like sleep disorders

作　　者：解俊樊 赵雪琪 高进贤 任艳丽 杨兴文 邵玉峰 侯一平[1] Xie Junfan;Zhao Xueqi;Gao Jinxian;Ren Yanli;Yang Xingwen;Shao Yufeng;Hou Yiping(Department of Neuroscience,Anatomy,Histology and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学基础医学院神经科学研究所,人体解剖与组织胚胎学教研室,甘肃省新药临床前重点实验室,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2024年第4期71-76,共6页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金资助项目(82001396);甘肃省自然科学基金资助项目(20JR5RA228)。

摘　　要：焦虑症常与睡眠障碍共存且相互作用,一方面睡眠障碍可引起焦虑,另一方面焦虑患者常出现失眠、睡眠片段化等焦虑样睡眠改变。基底外侧杏仁核和中央杏仁核与脑内多个睡眠-觉醒调控核团存在纤维联系,是调控焦虑样行为与睡眠的关键核团。本研究总结杏仁核解剖结构、纤维联系,以及杏仁核调节焦虑样行为与睡眠障碍的作用机制与神经环路,对进一步理解睡眠与焦虑相互作用的潜在机制具有重要意义,为临床治疗焦虑症和睡眠障碍提供理论基础。Anxiety and sleep disorder are related to each other in a bidirectional way;generally,sleep disor-ders cause anxiety and people suffering from anxiety disorders experience insomnia and sleep fragmentation.The basolateral and central amygdala project to the nuclei involved in the regulation of sleep-wake states,thus playing a key role in regulating anxiety-like behavior and sleep disturbance.In this review,we summarized the anatomic structure and fiber connections of amygdalae,and their mechanisms and neural circuits that act on anxiety-like behavior and sleep disturbance so as to provide new insight into the interaction between anxiety and sleep,and come up with fundamental theories for anxiety and sleep disorder treatment.

关 键 词：焦虑 睡眠-觉醒时相 杏仁核 睡眠障碍 快动眼睡眠 非快动眼睡眠 

分 类 号：R338[医药卫生—人体生理学]