菊科橐吾属植物中艾里莫芬烷型倍半萜化合物细胞毒性研究进展  

Advances in the study of the cytotoxicity of eremophilane sesquiterpene compounds in Ligularia Cass.(Asteraceae)

作　　者：杨立苑 程菊 陈建军 石小艺 陈晓峥 谢小冬 Yang Liyuan;Cheng Ju;Chen Jianjun;Shi Xiaoyi;Chen Xiaozheng;Xie Xiaodong(School of Basic Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Institute of Genetics,School of Basic Medicine,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China;State Key Experiment of Functional Organic Molecular Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学基础医学院,甘肃兰州730000 [2]兰州大学基础医学院遗传学研究所,甘肃兰州730000 [3]兰州大学化学化工学院功能有机分子化学国家重点实验室,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2024年第4期83-87,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省科技重大专项资助项目(22ZD1FA001);兰州市科技局新冠肺炎防控技术研究资助项目(2020-XG-37)。

摘　　要：艾里莫芬烷型倍半萜是由15个碳原子组成的双环倍半萜,主要从菊科植物橐吾属植物中提取,具有抗肿瘤、抗菌、抗炎等生物活性。艾里莫芬烷型倍半萜的基本结构类型主要包括内酯环、二聚体、呋喃环、降碳型和C19等。本文综述了艾里莫芬烷型倍半萜的相关结构及其潜在的细胞毒性,阐述其特定化学结构特点对抗肿瘤活性的影响,以期为研究其抗肿瘤的临床治疗效果提供参考。Eremophilane sesquiterpene is a double-ring sesquiterpene composed of 15 carbon atoms,mainly extracted from Ligularia,and has anti-tumor,antibacterial,anti-inflammatory and other biological activities.The basic structure types of irimofen alkane sesquiterpenes mainly include a lactone ring,dimer,furan ring,carbon reduction type and C19.In this paper,the structures and potential cytotoxicity of irimofenane sesqui-terpenes were reviewed,and the effects of specific known chemical structures on the anti-tumor activity were described,in order to provide reference for the study of their anti-tumor clinical therapeutic effects.

关 键 词：小分子化合物 艾里莫芬烷型倍半萜 抗肿瘤药物 细胞毒性 构效关系 

分 类 号：R96[医药卫生—药理学]