药物减轻心肌缺血再灌注损伤机制研究的进展  

Research progress on the mechanism of drugs in attenuating myocardial ischemia-reperfusion injury

作　　者：邢阳 冷玉芳[1,2] 赵潇 李东阳[4] 兰金辉 刘振 李东斌 王玉 常利娅 赵紫岑 Xing Yang;Leng Yufang;Zhao Xiao;Li Dongyang;Lan Jinhui;Liu Zhen;Li Dongbin;Wang Yu;Chang Liya;Zhao Zicen(The First Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Department of Anesthesiology,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China;The Third Clinical Medical School,Jilin University,Changchun 130000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院麻醉手术科,甘肃兰州730000 [3]西安交通大学第二附属医院消化内科,陕西西安710004 [4]吉林大学白求恩第三临床医学院,吉林长春130000

出　　处：《兰州大学学报（医学版）》2024年第4期88-94,共7页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金资助项目(82260381);兰州大学医学教育创新发展项目(lzuyxcx-2022-108)。

摘　　要：心肌缺血再灌注损伤常见于心肌梗塞、心肌缺血等,其发病率、死亡率高,且缺乏防治措施。积极探究防治心肌缺血再灌注损伤是临床研究的热点,近5年有关药物减轻心肌缺血再灌注损伤及其机制的研究较多,也取得了一些进展。本文着重介绍近5年关于药物通过抑制铁死亡、细胞凋亡、坏死性凋亡、细胞焦亡、氧化应激、钙超载、自噬调控、内质网应激、能量代谢等机制减轻心肌缺血再灌注损伤的实验研究和临床观察,及利用纳米技术、冠状动脉内给药技术等防治心肌缺血再灌注损伤的新成果,为心肌缺血再灌注损伤防治和研究提供理论依据。Myocardial ischemia-reperfusion injury is common in myocardial infarction and myocardial ischemia,having a high incidence,high mortality and insufficient prevention and treatment measures.Actively exploring the prevention and treatment of myocardial ischemia-reperfusion injury has been a focus of clinical research.In the past five years,new progress has been made in the study of drugs that can reduce myocardial ischemia-reperfusion injury and the mechanisms.This article focused on the experimental research and clini-cal observation of drugs in the prevention and treatment of myocardial ischemia-reperfusion injury by in-hibiting ferroptosis,apoptosis,necroptosis,pyrosis,oxidative stress and calcium overload and regulating autophagy,endoplasmic reticulum stress and energy metabolism,and also the latest achievements in the pre-vention and treatment of myocardial ischemia-reperfusion injury by nanotechnology and intracoronary drug administration in the past five years,so as to provide a theoretical basis for the prevention and treatment of myocardial ischemia-reperfusion injury.

关 键 词：药物 心肌缺血再灌注 器官保护 细胞凋亡 自噬 氧化应激 

分 类 号：R542.2[医药卫生—心血管疾病]