紫杉醇药物资源的研究概况  

Research Overview of Paclitaxel Drug Resources

作　　者：吴世龙 李妍妍 Wu Shilong;Li Yanyan(College of Chemistry,Chemical Engineering and Resource Utilization,Northeast Forestry University,Harbin 150040,China)

机构地区：[1]东北林业大学化学化工与资源利用学院,黑龙江哈尔滨150040

出　　处：《国土与自然资源研究》2024年第4期79-83,共5页Territory & Natural Resources Study

基　　金：国家林业和草原局野生植物保护管理项目(2020070321)。

摘　　要：紫杉醇是一种主要从红豆杉树皮中分离出的天然次生代谢产物,具有广泛而显著的抗肿瘤活性。虽然红豆杉的树叶、种子和根等部位都含有一定量的紫杉醇,但红豆杉生长缓慢,临床对紫杉醇的需求导致红豆杉大量被采伐,已造成严重的资源不足。目前获取紫杉醇的药物资源主要包括天然植物提取、化学合成、半化学合成、细胞培养和真菌发酵等途径。本文总结了现阶段红豆杉资源储量及紫杉醇合成方法,同时还介绍了相关的研究进展和未来的发展方向,为了解红豆杉及紫杉醇产业发展提供一定的理论依据和数据支持。Paclitaxel is a natural secondary metabolite isolated mainly from the bark of the Taxus tree and has a wide range of antitumor activities.Although the leaves,seeds,and roots of Sequoia contain some amount of Paclitaxel,the slow growth of Sequoia and the clinical demand for Paclitaxel would cause a large amount of Sequoia to be harvested.The current pharmaceutical resources for obtaining Paclitaxel mainly include natural plant extracts,chemical synthesis,semi-chemical synthesis,cell culture and fungal fermentation.This paper summarizes the current reserves of Taxus resources and the methods of Paclitaxel synthesis,and also introduces the related research progress and future development direction,which provides some theoretical basis and data support for the industrialization of Taxus and Paclitaxel.

关 键 词：红豆杉 资源 紫杉醇 

分 类 号：R979.1[医药卫生—药品]