中国中老年女性脂质积累产物和内脏脂肪指数与膝骨关节炎的关联性  

Association of lipid accumulation products and visceral fat index with knee osteoarthritis in middle-aged and elderly Chinese women

作　　者：张浩运 孙泽文 赵夏[1] 于腾波 ZHANG Haoyun;SUN Zewen;ZHAO Xia;YU Tengbo(Department of Sports Medicine,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院运动医学科,山东青岛266003 [2]康复大学青岛医院(青岛市立医院) [3]青岛大学运动医学与健康研究院

出　　处：《青岛大学学报（医学版）》2024年第2期218-221,共4页Journal of Qingdao University(Medical Sciences)

基　　金：2021年度山东省重点研发计划项目(31741063)。

摘　　要：目的探讨中国中老年女性脂质积累产物(LAP)和内脏脂肪指数(VAI)与膝骨关节炎(KOA)的关联性。方法收集中国健康与养老追踪调查(CHARLS)数据库2011年的数据。采用Logistic回归和受试者工作特征(ROC)曲线分析LAP、VAI与KOA发病的关联。结果中国≥45岁女性KOA的患病率为34.01%(1257/3696)。单因素Logistic回归分析显示,LAP(OR=1.013,95%CI=1.012~1.014)、VAL(OR=1.137,95%CI=1.117~1.158)与KOA发病呈正相关。在调整混杂因素后,LAP(OR=1.003,95%CI=1.002~1.004)和VAI(OR=1.048,95%CI=1.029~1.069)仍与KOA发病呈显著正相关。LAP的ROC曲线下面积(AUC)为0.725(95%CI=0.709~0.741),VAI的AUC为0.630(95%CI=0.613~0.647)。结论LAP和VAI增高是KOA发病的危险因素。LAP对中老年女性KOA的发病有一定的预测价值。Objective To evaluate the association of lipid accumulation products(LAPs)and visceral adiposity index(VAI)with knee osteoarthritis(KOA)in middle-aged and elderly Chinese women.Methods The data were collected from the China Health and Retirement Longitudinal Study(CHARLS)database in 2011.The association of LAPs and VAI with the development of KOA was analyzed using the Logistic regression and receiver operating characteristic(ROC)curve.Results The prevalence of KOA was 34.01%(1257/3696)in Chinese women aged≥45 years.Univariate Logistic regression analysis showed that increased LAPs(OR=1.013,95%CI=1.012-1.014)and VAL(OR=1.137,95%CI=1.117-1.158)were associated with the development of KOA.After adjustment for confounding factors,increased LAPs(OR=1.003,95%CI=1.002-1.004)and VAI(OR=1.048,95%CI=1.029-1.069)were still significantly associated with the development of KOA.The area under the ROC curve was 0.725(95%CI=0.709-0.741)for LAPs and 0.630(95%CI=0.613-0.647)for VAI.ConclusionIncreased LAPs and VAI are risk factors for the development of KOA.LAPs has certain value in predicting the development of KOA in middle-aged and elderly women.

关 键 词：膝骨关节炎 脂质沉积指数 腹内脂肪 

分 类 号：R684.3[医药卫生—骨科学] R194.3[医药卫生—外科学]