类器官技术在乳腺癌研究中的现状及应用  

Status and application of organoid technology in breast cancer research

作　　者：陈芷彦 伍秋苑 邓裕华 周丹 CHEN Zhiyan;WU Qiuyuan;DENG Yuhua;ZHOU Dan(The First Clinical College,Guangdong Medical University,Zhanjiang 524000,China;The First People's Hospital of Foshan)

机构地区：[1]广东医科大学第一临床医学院,524000 [2]佛山市第一人民医院

出　　处：《天津医药》2024年第6期668-672,共5页Tianjin Medical Journal

基　　金：广东省基础与应用基础研究基金区域联合基金项目(地区培育项目)(2022A1515140091);广东省中医药局中医药科研项目(20231324)。

摘　　要：类器官能够很好地模拟肿瘤的异质性,包括肿瘤微环境、免疫反应等,这有助于更准确地预测患者对药物的反应和治疗效果,且可以在药物进入体内前进行药物筛选,从而节约临床试验的时间和成本。然而,类器官的研究仍面临一些挑战,如技术限制、伦理问题等。就乳腺癌类器官的研究进展,包括类器官的定义、发展历程、优势以及在乳腺癌研究中的应用进行综述。Organoids can well simulate the heterogeneity of tumors,including tumor microenvironment and immune response,which helps to more accurately predict patient responses to drug and treatment effects.Organoids can be used for drug screening before drugs enter body,thus reducing the time and cost of clinical trials.However,research on tissue-organoids still faces some challenges,such as technical limitation and ethical issue.This review mainly introduces the progress in the research of breast cancer organoids,including the definition of organoids,development history,advantages and application in breast cancer research.

关 键 词：类器官 乳腺肿瘤 药物筛选 个性化治疗 

分 类 号：R655.8[医药卫生—外科学]