小窝的作用机制及其影响通路  

Mechanism of action of Caveolae and its impact pathways

作　　者：杜秀 徐琳[1,2,3,4] 程苏 王艳茹 邵命海 Du Xiu;Xu Lin;Cheng Su;Wang Yan-ru;Shao Ming-hai(Department of Nephrology,Affiliated Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institute of Traditional Chinese Medicine for Nephrology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Ministry of Education Key Laboratory of Hepatorenal Diseases,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Municipal Key Laboratory for Clinical Practices of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肾病科,上海201203 [2]上海中医药大学中医肾病研究所,上海201203 [3]上海中医药大学肝肾疾病病症教育部重点实验室,上海201203 [4]上海市中医临床重点实验室,上海201203

出　　处：《临床肾脏病杂志》2024年第5期412-416,共5页Journal Of Clinical Nephrology

基　　金：国家自然科学基金资助项目(81973807,82174289);上海市卫生健康委员会科研项目计划(20214Y0382)。

摘　　要：小窝(Caveolae)作为跨细胞途径的重要组成部分,在不破坏细胞稳态的基础上,实现物质的跨细胞转运。在肾脏中,血清大分子物质如白蛋白通过小窝穿越肾小球滤过屏障。白蛋白的跨细胞运输在蛋白尿的病理学中起到至关重要的作用,其中小窝的重要性也不言而喻。然而,肾脏中小窝影响白蛋白跨细胞运输的作用机制及其信号通路在很大程度上仍然未知。本文总结了近年来小窝影响白蛋白跨细胞运输的调控研究,了解其相关作用机制与影响通路可能在预防和减轻蛋白尿中提供潜在的治疗靶点。As an important component of transcellular pathway,Caveolae enables the transcellu-lar transport of substances without disrupting cellular homeostasis.In kidney,albumin crosses glomerular filtration barrier(GFB)via Caveolae.Transcellular transport of albumin plays a crucial role in the patholo-gy of proteinuria.Thus the importance of Caveolae cannot be overstated.However,the acting mechanism of Caveolae affecting transcellular albumin transport in kidney and their signaling pathways have re-mained largely elusive.This review summarized the latest studies on the regulation of Caveolae affecting transcellular albumin transport.Thus elucidating the relevant mechanisms of action and understanding the pathways of influence may provide potential therapeutic targets in the prevention and alleviation of proteinuria.

关 键 词：小窝 小窝蛋白 血管生成素类 血管内皮生长因子 

分 类 号：R334.1[医药卫生—人体生理学]