光学传感器在尿酸检测中的应用研究进展  

Research Progress on the Application of Optical Sensors in Uric Acid Detection

作　　者：雷帅 谢洪雨 许文涛[2] 杨倩 LEI Shuai;XIE Hongyu;XU Wentao;YANG Qian(School of Public Health,Hebei University,Baoding 071000,China;Department of Nutrition and Health,China Agricultural University,Beijing 100190,China;Hebei Key Laboratory of Public Health Safety,Baoding 071000,China)

机构地区：[1]河北大学公共卫生学院,河北保定071000 [2]中国农业大学营养与健康系,北京100190 [3]河北省公共卫生安全重点实验室,河北保定071000

出　　处：《防化研究》2024年第1期56-63,71,共9页CBRN DEFENSE

基　　金：国家自然科学基金项目(32372437);河北省高层次人才资助项目(C20231100);河北省高等学校科学技术研究项目(QN2022073);河北大学医学学科培育项目重点项目(2022A06)。

摘　　要：尿酸是一种重要的抗氧化剂,有助于维持体内正常代谢。尿酸浓度异常会导致高尿酸血症、痛风、帕金森病等疾病。因此,实现尿酸的高效灵敏检测对临床诊断和治疗至关重要。光学传感器具有分析速度快、操作简便、高选择性和高灵敏度等优势,已成为尿酸检测领域的主要研究方向之一。本文系统阐述了比色传感器、荧光传感器、化学发光传感器、表面增强拉曼光谱传感器、表面等离子体共振传感器等光学传感器的研究现状,归纳总结了不同类型传感器的特点;介绍了量子点、金属有机骨架等纳米材料在传感器中的应用,展望了基于光学传感器的尿酸检测技术的发展前景,以期为尿酸检测和光学传感器的发展提供参考依据和新思路。Uric acid is an important antioxidant that helps maintain normal metabolism in the body.Abnormal uric acid concentration can lead to diseases such as hyperuricemia,gout and Parkinsonism.Therefore,efficient and sensitive detection of uric acid is crucial for clinical diagnosis and treatment.Optical sensors,with advantages such as fast analysis speed,simple operation,high selectivity,and high sensitivity,have become one of the main research directions in the field of uric acid detection.In this review,current research status on optical sensors such as colorimetric sensors,fluorescence sensors,chemiluminescence sensors,surface-enhanced Raman spectroscopy sensors,surface plasmon resonance sensors,and the features of various optical sensors were systematically elaborated and outlined.The application of nanomaterials like quantum dots and metal-organic frameworks in optical sensors was also presented.Finally,the development trend of uric acid detection based on optical sensors was envisaged.This review is expected to provide reference and new ideas for the uric acid detection and the development of optical sensors.

关 键 词：尿酸 光学传感器 检测 

分 类 号：R446.1[医药卫生—诊断学]