可天然降解的聚己内酯基农药缓释微球  

Naturally Degradable Sustained-release Microspheres of Polycaprolactone Loaded with Pesticide

作　　者：雷萌萌 陈舒怡 孙玙璠 陈静 丁师杰 LEI Mengmeng;CHEN Shuyi;SUN Yufan;CHEN Jing;DING Shijie(Faculty of Chemical Engineering,Huaiyin Institute of Technology/Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province,Huai’an Jiangsu 223003,China)

机构地区：[1]淮阴工学院化学工程学院/江苏省凹土资源利用重点实验室,江苏淮安223003

出　　处：《淮阴工学院学报》2024年第2期35-39,共5页Journal of Huaiyin Institute of Technology

基　　金：国家自然科学基金“叔氨基(甲基)丙烯酸酯系列聚合物刷pH响应行为的研究”(21174046)。

摘　　要：传统农药使用效期短,有效利用率低。为了实现“减施增效”的目标,提出了“农药缓释”的概念。目前市场上的微胶囊农药缓释剂产品,其囊材多为不可天然降解的合成高分子材料,完成活性成分释放后仍留在环境中,对环境污染严重。针对该问题,以可天然降解的高分子材料聚己内酯为载体、高效氯氰菊酯为药物模型,采用O/W溶剂挥发法,制备可天然降解的聚己内酯载高效氯氰菊酯缓释微球,研究溶剂挥发时间、离心速率、药物投放量对微球制备的影响。制得载药微球,载药量最高为49.60%、包封率最高为97.13%。药物缓释的整个过程没有明显的突释,且缓释时间较长,缓释效果明显。用Ritger-Peppas模型分析药物缓释动力学,结果表明该微球释放机理为药物扩散和骨架溶蚀扩散的结合。Traditional pesticides have a short shelf life and low effective utilization rate.In order to achieve the goal of"reducing application and increasing efficiency",the concept of"sustained-release pesticide"is proposed.At present,the sustained-release microcapsules of pesticide in the market are mostly made of synthetic polymer materials that cannot be naturally degraded.After the release of ac-tive ingredients,they still remain in the environment,causing serious pollution.To address this issue,by using polycaprolactone as the carrier and beta-cypermethrin as the drug model,naturally degradable sustained-release microspheres of polycaprolactone loaded with cypermethrin were prepared by O/W sol-vent evaporation method.The effects of solvent evaporation time,centrifugation rate,and drug dosage on the preparation of microspheres were investigated.The maximum drug loading and the maximum encap-sulation efficiency of the prepared microspheres were 49.60%and 97.13%,respectively.The entire process of drug sustained release did not show sudden release,with a fairly long sustained release time,indicating a significant sustained release effect.The Ritger-Peppas model was used to analyze the drug release kinetics,and the results showed that the release mechanism of the microspheres was a combination of drug diffusion and skeleton dissolution diffusion.

关 键 词：聚己内酯 高效氯氰菊酯 O/W溶剂挥发 Ritger-Peppas模型 

分 类 号：TQ450.14[化学工程—农药化工] TD985[矿业工程—选矿]