Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms  

作　　者：Yan-Qiang Huang Yuan-Feng Li Yong Liu Lin-Qi Shi 

机构地区：[1]Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance,Youjiang Medical University for Nationalities,Baise,533000,China [2]Translational Medicine Laboratory,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China [3]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325001,China [4]State Key Laboratory of Medicinal Chemical Biology,Key Laboratory of Functional Polymer Materials of Ministry of Education,and Institute of Polymer Chemistry,College of Chemistry,Nankai University,Tianjin,300071,China

出　　处：《Chinese Journal of Polymer Science》2024年第6期718-728,共11页高分子科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22275043,52203184,52293380 and 52293383);Startup Fund of Wenzhou Institute,University of Chinese Academy of Sciences(Nos.WIUCASQD2021022 and WIUCASQD2021019).

摘　　要：Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative nanomedicines.In this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery platform.The micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial biofilms.An important advantage of our micelles lies in their interaction with local bacterial lipases within biofilms.These lipases triggered rapid micelle degradation,releasing triclosan in a controlled manner.This liberated triclosan effectively eliminated bacteria embedded in the biofilms.Notably,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and safety.This finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial biofilms.Our triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial biofilms.By harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关 键 词：Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity 

分 类 号：R318[医药卫生—生物医学工程] TQ317[医药卫生—基础医学]