Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications  

作　　者：Feng-Ming Yin Li-Li Wu Shu-Sheng Li Xiao-Na Pan Xiao-Li Zhu Xu-Bao Jiang Xiang Zheng Kong 

机构地区：[1]College of Chemistry and Chemical Engineering,University of Jinan,Jinan,250022,China [2]Shandong Institute for Product Quality Inspection,Jinan,250102,China [3]College of Chemical Engineering,Tianjin University,Tianjin,300072,China

出　　处：《Chinese Journal of Polymer Science》2024年第6期826-837,共12页高分子科学（英文版）

基　　金：supported by Nature Science Foundation of Shandong Province,China(Nos.ZR2021MB112 and ZR2022MB051);Science and Technology Bureau of Jinan City(2021GXRC105);Postdoctoral Science Foundation of China(2022M712343);as well as by Basic and Applied Basic Research Foundation(2020A1515110374)of Guangdong Province,China.

摘　　要：Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent years.However,the underlying interaction between their fluorescent properties and phase transition remains unclear.In this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as pH.Notably,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence emission.We further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous solutions.Moreover,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of doxorubicin.Our study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关 键 词：POLYETHYLENEIMINE Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release 

分 类 号：O657.3[理学—分析化学] TQ317[理学—化学]