银杏叶提取物对糖尿病肾病患儿TGF-β1、HGF水平的影响  

Effects of Ginkgo biloba extract on TGF⁃β1 and HGF levels in children with diabetic nephropathy

作　　者：王延鑫 吴志全 杜斯斯 魏贯南 吴新爱 WANG YanXin;WU Zhiquan;DU Sisi;WEI Guannan;WU Xinai(Department of Pediatrics of Traditional Chinese Medicine,Shijiazhuang Maternal and Child Health Hospi-tal,Shijiazhuang,Hebei,China,050000;Department of Spleen and Stomach Diseases,Shijiazhuang Ping'an Hospital,Shijiazhuang,Hebei,China,050000)

机构地区：[1]石家庄市妇幼保健院中医儿科,河北石家庄050000 [2]石家庄平安医院脾胃病科,河北石家庄050000

出　　处：《分子诊断与治疗杂志》2024年第4期721-724,729,共5页Journal of Molecular Diagnostics and Therapy

基　　金：石家庄市科学技术研究与发展计划项目(201460833)。

摘　　要：目的探究银杏叶提取物用于糖尿病肾病患儿对其转化生长因子TGF-β1、肝细胞生长因子HGF水平的影响。方法回顾性选取2020年1月至2023年2月期间于石家庄市第六医院接受治疗的糖尿病肾损伤患儿资料188份,分为常规组(82例,常规西医治疗)和研究组(106例,银杏叶提取物+常规治疗),比较两组临床疗效,治疗前后肾功能相关指标、转化生长因子-β1(TGF-β1)、肝细胞生长因子(HGF)水平差异及不良反应发生情况。结果研究组治疗总有效率92.45%,高于常规组81.71%,差异有统计学意义(χ^(2)=4.972,P<0.05);治疗后两组血肌酐(Scr)、尿素氮(BUN)、尿白蛋白排泄率(UAER)、24h尿蛋白定量(24hUP)等肾功能指标及血清TGF-β1水平与治疗前比较均降低,而血清HGF水平则升高,且研究组上述指标变化幅度均大于常规组,差异有统计学意义(t=6.024、7.317、11.651、5.486、8.863、10.345,P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论银杏叶提取物有利于糖尿病肾病患儿治疗,可通过调节患者TGF-β1、HGF水平显著改善患者肾功能,提高临床疗效。Objective To investigate the effects of Ginkgo biloba extract on TGF⁃β1 and HGF lev⁃els in children with diabetic nephropathy.Methods A total of 188 diabetic children with kidney injury who re⁃ceived treatment at Shijiazhuang Sixth Hospital from January 2020 to February 2023 were retrospectively select⁃ed.They were divided into two groups:the conventional group(82 cases,treated with conventional Western medicine)and the study group(106 cases,treated with ginkgo biloba extract+conventional treatment).The clinical efficacy of the two groups was compared.The differences in renal function related indexes,levels of transforming growth factor⁃β1(TGF⁃β1),hepatocyte growth factor(HGF),and the occurrence of adverse re⁃actions before and after treatment were also compared.Results The total effective rate of the study group was 92.45%,which was higher than that of the conventional group at 81.71%.This difference was statistically signif⁃icant(c2=4.972,P<0.05).After treatment,renal function indexes such as blood creatinine(Scr),urea nitrogen(BUN),urinary albumin excretion rate(UAER),24 h urinary protein quantity(24hUP)and serum TGF⁃β1 level decreased in both groups compared to before treatment.Additionally,serum HGF level increased.The changes in these indexes in the study group were greater in the study group than in the conventional group,with statistically significant differences(t=6.024,7.317,11.651,5.486,8.863,10.345,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Gink⁃go biloba extract is beneficial in treating children with diabetic nephropathy.It can significantly improve renal function and clinical efficacy by adjusting TGF⁃β1 and HGF levels in patients.

关 键 词：糖尿病肾病 银杏叶提取物 转化生长因子-Β1 肝细胞生长因子 

分 类 号：R272[医药卫生—中医儿科学]