参芎葡萄糖注射液联合达格列净对早期2型糖尿病肾病患者肾功能、尿蛋白的影响  

Effects of Shenxiong glucose injection combined with Daglipzin on renal function and urinary protein in patients with early type 2 diabetic nephropathy

作　　者：常丽 郭东亮[1] 刘继红 CHANG Li;GUO Dongliang;LIU Jihong(Department of Endocrinology,Linquan People's Hospital,Fuyang,Anhui,China,236400)

机构地区：[1]安徽省阜阳市临泉县人民医院内分泌科,安徽阜阳236400

出　　处：《分子诊断与治疗杂志》2024年第5期864-867,876,共5页Journal of Molecular Diagnostics and Therapy

基　　金：阜阳市科技局科研基金资助项目(FK202081-56)。

摘　　要：目的 探讨参芎葡萄糖注射液联合达格列净对早期2型糖尿病(T2DM)肾病患者肾功能、尿蛋白的影响。方法 选取2021年1月至2023年1月临泉县人民医院收治的早期T2DM肾病患者100例为研究对象,根据治疗方法分为研究组(参芎葡萄糖注射液联合达格列净治疗,n=57)和对照组(达格列净治疗,n=43)。比较两组肾功能、尿蛋白、临床疗效及不良反应。结果 治疗后研究组尿素氮(BUN)、血肌酐(Scr)低于对照组,差异有统计学意义(t=3.376、3.010,P<0.05);治疗后研究组内生肌酐清除率(Ccr)、肾小球滤过率(eGFR)高于对照组,差异有统计学意义(t=2.377、2.802,P<0.05)。治疗后研究组尿微量白蛋白(UALB)、尿微量白蛋白与肌酐比值(UACR)水平低于对照组,差异有统计学意义(t=6.728、4.994,P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(χ^(2)=5.697,P<0.05)。两组不良反应发生率比较差异无统计学意义(χ^(2)=0.018,P>0.05)。结论 参芎葡萄糖注射液联合达格列净可以更好地改善早期T2DM肾病患者肾功能,减少尿蛋白,具有良好的治疗效果。Objective To investigate the effects of Shenxiong glucose injection combined with Daglipzin on renal function and urinary protein in patients with early type 2 diabetes mellitus(T2DM).Meth⁃ods A total of 100 patients with early T2DM nephropathy treated at Linquan County People's Hospital from January 2021 to January 2023 were selected as study subjects.They were divided into two groups based on treatment methods:thestudy group(Shenqin glucose injection combined with daglizin treatment,n=57)and the control group(daglizin treatment,n=43).Renal function,urinary protein levels,clinical efficacy,and ad⁃verse reactions were compared between the two groups.Results After treatment,the levels of blood urea ni⁃trogen(BUN)and serum creatinine(Scr)in the study group were lower than those in the control group,and the differences were statistically significant(t=3.376,3.010,P<0.05).After treatment,the creatinine clear⁃ance(Ccr)and glomerular filtration rate(eGFR)in the study group were higher than those in the control group,and the differences were statistically significant(t=2.377,2.802,P<0.05).After treatment,the levels of urinary microalbumin(UALB),urinary microalbumin to creatinine ratio(UACR)of the study group were lower than those of the control group,and the differences were statistically significant(t=6.728,4.994,P<0.05).The effective rate of the study group was higher than that of the control group,and the differences were statistically significant(χ^(2)=5.697,P<0.05).There was no significant difference in the incidence of adverse re⁃actions between the two groups(χ^(2)=0.018,P>0.05).Conclusion Shenxiong glucose injection,when com⁃bined with daglizin can improve renal function and reduce urinary protein in patients with early T2DM nephropathy.This treatment has been shown to have a positive therapeutic effect.

关 键 词：参芎葡萄糖注射液 达格列净 2型糖尿病肾病 肾功能 尿蛋白 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]