慢性阻塞性肺疾病急性加重患者外周血红细胞分布宽度、嗜酸性粒细胞、B型钠尿肽的诊断价值及相关性分析  

Diagnostic value and correlation analysis of red blood cell distribution width,eosinophils,and B⁃type natriuretic peptide in peripheral blood of patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：宋玉良 王永 SONG Yuliang;WANG Yong(Department of Respiratory and Critical Care Medicine,the Fifth People's Hospital,Fuyang,Anhui,China,236600)

机构地区：[1]安徽省阜阳市第五人民医院呼吸与危重症医学科,安徽阜阳236600

出　　处：《分子诊断与治疗杂志》2024年第5期890-893,903,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康委科研项目(AHWJ2021a035)。

摘　　要：目的分析慢性阻塞性肺疾病急性加重(AECOPD)患者红细胞分布宽度(RDW)、嗜酸性粒细胞(EOS)、B型钠尿肽(BNP)的相关性及诊断价值。方法选择2020年1月至2022年8月阜阳市第五人民医院收治的102例AECOPD患者作为AECOPD组进行分析,同时选取同期在医院进行治疗的慢性阻塞性肺疾病(COPD)稳定期患者49例为参照组,对比RDW、EOS、BNP水平及第1秒呼气容积(FEV1)、用力呼气1秒最大呼气容积预计百分比(FEV1%pred)、第1秒用力呼气容积/用力肺活量比值(FEV1/FVC)、最大呼气中期流速占预计值百分比(PEF)等肺功能指标在两组间的差异,分析RDW、EOS、BNP在AECOPD患者中的相关性及诊断中的价值。结果相较于参照组,AECOPD组RDW、EOS、BNP水平均上升,差异均有统计学意义(t=5.890、6.880、6.267,P<0.05);相较于参照组,AECOPD组FEV1、FEV1%pred、FEV1/FVC及PEF水平均下降,差异均有统计学意义(t=5.857、7.175、6.022、6.767,P<0.05);Pearson分析显示,RDW、EOS、BNP均与AECOPD患者的FEV1、FEV1%pred、FEV1/FVC、PEF呈负相关(P<0.05);ROC曲线分析显示,RDW、EOS、BNP诊断AECOPD的下曲线面积(AUC)分别为0.776、0.803、0.777,而三者联合检测的AUC为0.911(P<0.05)。结论RDW、EOS、BNP在AECOPD患者中异常上升,且与患者肺功能呈负相关,通过对上述指标水平的联合检测对诊断AECOPD有较好的应用价值。Objective To analyze the correlation and diagnostic value of red blood cell distribu⁃tion width(RDW),eosinophilic granulocyte(EOS)and b⁃type natriuretic peptide(BNP)in peripheral blood of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A retro⁃spective analysis was performed on 102 patients with AECOPD admitted to Fuyang Fifth People's Hospital from January 2020 to August 2022 as the AECOPD group.At the same time,49 patients with stable chronic obstructive pulmonary disease(COPD)who received treatment at the hospital during the same period were chosen as the reference group.The levels of RDW,EOS,BNP,and pulmonary function indexes such as FEV1,FEV1%pred,FEV1/FVC,PEF were compared between the two groups.The correlation and diagnostic value of RDW,EOS,and BNP in AECOPD patients were analyzed.Results Compared to the reference group,the levels of RDW,EOS,and BNP in the AECOPD group increased significantly(t=5.890,6.880,6.267,P<0.05).Additionally,the levels of FEV1,FEV1%pred,FEV1/FVC and PEF in the AECOPD group decreased significantly compared to the reference group(t=5.857,7.175,6.022,6.767,P<0.05);Pearson analysis showed that RDW,EOS,and BNP were negatively correlated with FEV1,FEV1%pred,FEV1/FVC and PEF in AECOPD patients(P<0.05).ROC curve analysis demonstrated that the area under the curve(AUC)of RDW,EOS,and BNP in the diagnosis of AECOPD was 0.776,0.803 and 0.777,respectively.The AUC for the combined detection of the three was 0.911(P<0.05).Conclusion RDW,EOS,and BNP are abnormally elevated in patients with AECOPD and are negatively correlated with lung function.The combined detection of these indicators has a good application value in the diagnosis of AECOPD.

关 键 词：红细胞分布宽度 嗜酸性粒细胞 B型钠尿肽 慢性阻塞性肺疾病急性加重 

分 类 号：R563.9[医药卫生—呼吸系统]