D-二聚体、C肽水平结合经皮氧分压在糖尿病周围神经病变中诊断价值  

The diagnostic value of D⁃dimer and C⁃peptide levels combined with percutaneous partial pressure of oxygen in diabetic peripheral neuropathy

作　　者：张冰荫 李辉 范瑾[1,2] 杨云 贾笑迪 杨幸幸 ZHANG Bingyin;LI Hui;FAN Jin;YANG Yun;JIA Xiaodi;YANG Xingxing(Taihe Hospital Affiliated to Wannan Medical College,Fuyang,Anhui,China,236600;Department of Endocrinology,Taihe County People's Hospital,Fuyang,Anhui,China,236600)

机构地区：[1]安徽省皖南医学院附属太和医院,安徽阜阳236600 [2]太和县人民医院内分泌科,安徽阜阳236600

出　　处：《分子诊断与治疗杂志》2024年第5期926-929,共4页Journal of Molecular Diagnostics and Therapy

基　　金：阜阳市自筹经费科技项目(FK202081081)。

摘　　要：目的探究D-二聚体、C肽水平结合经皮氧分压对糖尿病周围神经病变(DPN)的诊断价值。方法选取2022年1月至2023年1月于安徽省皖南医学院附属太和医院接受治疗的60例2型糖尿病合并DPN患者作为研究组,另纳入60例同期未合并DPN的2型糖尿病患者作为对照组。收集两组患者临床资料、生化指标等进行比较,多因素Logistic回归分析糖尿病患者周围神经病变的危险因素,并通过受试者临床特征(ROC)曲线分析D-二聚体、C肽水平结合经皮氧分压(TcPO_(2))对糖尿病周围神经病变的诊断价值。结果研究组患者BMI、进食后2 h C肽及TcPO_(2)水平明显低于对照组,差异有统计学意义(t=2.435、6.215、5.849,P<0.05)。糖尿病病程、血清尿酸(SUA)、糖化血红蛋白(HbA1c)、D-二聚体数值高于对照组,差异有统计学意义(t=6.677、5.789、5.621、5.285,P<0.05);多因素Logistics回归分析结果显示糖尿病病程、HbA1c、D-二聚体、进食后2hC肽、TcPO_(2)均是糖尿病患者周围神经病变的独立影响因素(P<0.05);ROC曲线分析结果显示D-二聚体、C肽水平、经皮氧分压三者单独检测及联合检测的曲线下面积(AUC)分别为:0.752、0.784、0.769、0.861,三者联合检测的诊断价值优于单一指标(P<0.05)。结论糖尿病患者血清C肽、经皮氧分压及血清D-二聚体三者联合检测对其是否发生周围神经病变具有较高诊断价值。Objective To explore the diagnostic value of D⁃dimer and C⁃peptide levels combined with percutaneous partial pressure of oxygen in diabetic peripheral neuropathy(DPN).Methods A total of 60 patients with type 2 diabetes combined with DPN treated at Taihe Hospital Affiliated to Wannan Medical College,Anhui Province from January 2022 to January 2023 were selected as the study group,and 60 patients with simple type 2 diabetes without DPN during the same period were included as the control group.Clinical data and biochemical indexes from both groups were collected and compared.The risk factors for peripheral neuropathy in diabetic patients were analyzed using multivariate logistic regression.The diagnostic value of D⁃dimer and C⁃peptide levels combined with transcutaneous partial pressure of oxygen(TcPO_(2))in diabetic pe⁃ripheral neuropathy was analyzed by receiver operating characteristic(ROC)curve analysis.Result The lev⁃els of BMI,2hC peptide after eating and TcPO_(2) in the study group were significantly lower than those in the control group,and the differences were statistically significant(t=2.435,6.215,5.849,P<0.05).The dura⁃tion of diabetes mellitus,serum uric acid(SUA),glycosylated hemoglobin(HbA1c)and D⁃dimer values were higher than those of control group,with statistical significance(t=6.677,5.789,5.621,5.285,P<0.05).The results of multi⁃factor logistics regression analysis showed that diabetes course,HbA1c,D⁃dimer,2hC peptide after eating and TcPO_(2) were independent influencing factors of peripheral neuropathy in diabetic patients(P<0.05).ROC curve analysis results showed that the area under the curve(AUC)of D⁃dimer,C⁃peptide level and percutaneous oxygen partial pressure were 0.752,0.784,0.769 and 0.861 respectively,and the diagnostic value of the combined detection of D⁃dimer,C⁃peptide level and percutaneous oxygen par⁃tial pressure was better than that of a single index(P<0.05).Conclusion The combined detection of serum C⁃peptide,percutaneous oxygen partial pressure an

关 键 词：糖尿病周围神经病变 D-二聚体 C肽 经皮氧分压 

分 类 号：R587.2[医药卫生—内分泌]