脂阿拉伯甘露聚糖抗原检测用于艾滋病病毒感染者和艾滋病患者结核病诊断的研究进展  

Progress in lipoarabinomannan antigen detection for tuberculosis diagnosis in people living with HIV/AIDS

作　　者：王美霁 李锋[2] Wang Meiji;Li Feng(Shanghai Institute of Infectious Disease and Biosecurity,Fudan University,Shanghai 200032,China;Department of Tuberculosis Center,Shanghai Public Health Clinical Center,Shanghai 201508,China)

机构地区：[1]复旦大学上海市重大传染病和生物安全研究院,上海200032 [2]上海市公共卫生临床中心结核病研究中心,上海201508

出　　处：《中华结核和呼吸杂志》2024年第5期475-480,共6页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：上海市市级科技重大专项(ZD2021CY001);上海市科技计划(21Y11901700,20Z11901002)。

摘　　要：结核病是艾滋病病毒感染者和艾滋病患者(people living with HIV/AIDS,PLWHA)死亡的主要原因,给其带来巨大的疾病负担,在PLWHA人群中早期筛查结核病,是降低传播、控制其病情发展的关键举措。脂阿拉伯甘露聚糖(lipoarabinomannan,LAM)是MTB的糖脂,可以在结核患者尿液中检测到,LAM有助于快速、准确诊断结核病。本文综述了LAM及其在PLWHA诊断中的应用与局限性,希望为PLWHA结核病的诊断提供参考依据。Tuberculosis(TB)is the leading cause of death among people living with HIV/AIDS(PLWHA),posing a significant disease burden.Early TB screening in PLWHA is a key intervention to reduce transmission and control disease progression.Lipoarabinomannan(LAM)is a glycolipid of Mycobacteriumtuberculosis(MTB)that can be detected in the urine of tuberculosis patients.LAM is useful for the rapid and accurate diagnosis of tuberculosis.This article reviews LAM and its application and limitations in the diagnosis of PLWHA,hoping to provide a reference for the diagnosis of tuberculosis in PLWHA.

关 键 词：脂阿拉伯甘露聚糖 早期筛查 结核病诊断 疾病负担 抗原检测 HIV/AIDS PLWHA LAM 

分 类 号：R512.91[医药卫生—内科学]