PD-1/PD-L1,PD-L2信号通路及其在宿主抗结核免疫中作用的研究进展  

Progress in PD-1/PD-L1, PD-L2 signaling pathway and its role in host anti-tuberculosis immunity

作　　者：喻晓雯 张其奥 谢建平[1] Yu Xiaowen;Zhang Qi′ao;Xie Jianping(Institute of Modern Biopharmaceuticals,School of Life Sciences,Southwest University,Chongqing 400715,China)

机构地区：[1]西南大学生命科学学院现代生物医药研究所,重庆400715

出　　处：《中华结核和呼吸杂志》2024年第5期485-489,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(82211530059);重庆市科卫联合医学科研项目(2022QNXM050)。

摘　　要：程序性死亡受体-1(PD-1)及其配体PD-L1和PD-L2在多种免疫细胞中表达,在机体响应结核分枝杆菌(MTB)感染的免疫反应中发挥着多重调控作用。机体响应MTB感染时,PD-1/PD-L1,PD-L2信号通路调控多种适应性免疫反应,操纵巨噬细胞对MTB的天然免疫应答、调节T细胞与巨噬细胞的相互作用。此外,PD-1/PD-L1,PD-L2信号通路在宿主对抗MTB感染时的炎症反应中发挥关键作用,本文也总结了PD-1/PD-L1,PD-L2信号通路在结核病的治疗和诊断中的潜能。Programmed cell death 1(PD-1)and its ligands,PD-L1 and PD-L2,expressed on a variety of immune cells,play multiple regulatory roles in the host immune response to Mycobacterium tuberculosis infection.In this study,we reviewed that the regulatory roles of PD-1/PD-L1,PD-L2 signaling in the host adaptive immune response,such as the innate response of macrophages,and the interaction between T cells and macrophages in response to MTB.In addition,during MTB infection,PD-1/PD-L1,PD-L2 signaling is also involved in the host inflammatory response,as well as the potential roles of PD-1/PD-L1,PD-L2 in the diagnosis and treatment of tuberculosis.

关 键 词：调节T细胞 巨噬细胞 信号通路 免疫细胞 免疫反应 天然免疫应答 炎症反应 结核病 

分 类 号：R52[医药卫生—内科学]