高低相对分子质量透明质酸失衡在大气颗粒物致呼吸系统炎症中作用的研究进展  

Research progress on the role of imbalanced high and low molecular weight hyaluronic acid in respiratory system inflammation caused by atmospheric particulate matter

作　　者：阳晓燕[1] 魏岚[1] 查玉娥 李立[1] 王秦[1] Yang Xiaoyan;Wei Lan;Zha Yu′e;Li Li;Wang Qin(Key Laboratory of Environment and Human Health,Institute of Environmental Health/Chinese Center for Disease Control and Prevention,Beijing 100021,China)

机构地区：[1]中国疾病预防控制中心环境与人群健康重点实验室,中国疾病预防控制中心环境与健康相关产品安全所,北京100021

出　　处：《中华预防医学杂志》2024年第5期608-614,共7页Chinese Journal of Preventive Medicine

基　　金：中国疾病预防控制中心青年科研基金(2022A302)。

摘　　要：大气颗粒物可引起呼吸系统炎症,低相对分子质量透明质酸(HA)是炎症级联反应的关键作用靶点。本综述从HA的合成与分解、颗粒物与高相对分子质量量透明质酸(HMW-HA)的降低以及相对低分子质量透明质酸(LMW-HA)的增加、LMW-HA与呼吸系统炎症三个方面综述了大气颗粒物通过HMW-HA/LMW-HA失衡引起呼吸系统炎症的可能通路及作用靶点,并进一步列举了针对部分靶点的抑制剂和治疗药物,为大气颗粒物致呼吸系统炎症机制及后续研究需关注的薄弱点提供科研线索。Atmospheric particulate matter has an association with respiratory system inflammation,and low molecular weight hyaluronic acid(LMW-HA)is a key biomarker of inflammatory cascade reaction.This review summarized the possible pathways and biomarkers of atmospheric particulate matter causing respiratory system inflammation through high molecular weight hyaluronic acid(HMW-HA)/LMW-HA imbalance,including the synthesis and decomposition of HA,the reduction of particulate matter and HMW-HA,the increase of LMW-HA,and the relationship between LMW-HA and respiratory system inflammation.Furthermore,inhibitors and therapeutic drugs targeting certain biomarkers were further listed.This review could shed light on the mechanism of respiratory system inflammation caused by atmospheric particulate matter and the weak points that need attention in subsequent research.

关 键 词：大气颗粒物 低分子量透明质酸 透明质酸合成酶 

分 类 号：R122[医药卫生—环境卫生学]