我国城镇掌跖脓疱病的流行病学特征和经济负担分析  

Epidemioloical characteristics and economic burden analysis of palmoplantar pustulosis in urban areas of China

作　　者：张芊[1] 冯菁楠 郭金竹[1] 卓琳[1] 许璐 刘立立 高培[2] 王胜锋[2] 詹思延[3] 王文慧[1] Zhang Qian;Feng Jingnan;Guo Jinzhu;Zhuo Lin;Xu Lu;Liu Lili;Gao Pei;Wang Shengfeng;Zhan Siyan;Wang Wenhui(Department of Dermatology,Peking University Third Hospital,Beijing 100191,China;Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Research Center of Clinical Epidemiology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院皮肤科,北京100191 [2]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [3]北京大学第三医院临床流行病学研究中心,北京100191

出　　处：《中华预防医学杂志》2024年第5期642-648,共7页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81973146,82173616);北京大学第三医院人才孵育基金(Y80446-09)。

摘　　要：目的分析我国掌跖脓疱病的流行病学特征及疾病的经济负担。方法使用2012年1月1日至2016年12月31日我国城镇职工和城镇居民医疗保险数据库数据开展回顾性研究。通过国际疾病分类代码和中文诊断名称来识别掌跖脓疱病患者,并估算患病率、发病率和费用。根据年龄和性别进行亚组分析,并进行敏感性分析来考察结果稳健性。基于我国2010年全国人口普查数据计算年龄调整的标准化患病率和发病率。结果2016年我国掌跖脓疱病患病率和发病率分别为2.730/10万(95%CI:2.218/10万~3.242/10万)和1.556/10万(95%CI:1.154/10万~1.958/10万),女性患病率(2.910/10万)高于男性患病率(2.490/10万,χ^(2)=97.48,P=0.001),同时女性发病率(1.745/10万)高于男性发病率(1.418/10万,χ^(2)=85.02,P=0.001);年龄最高峰为30~39岁,在20岁以下人群中0~3岁年龄组存在小高峰。2012—2016年每位患者的就诊次数为(2.44±0.04)次,每年的人均总费用为(982.40±39.19)元。结论2016年我国掌跖脓疱病的患病率和发病率女性均高于男性,患病率和发病率峰值年龄在30~39岁。Objective To analyze the epidemiological characteristics and economic burden of palmoplantar pustulosis(PPP)in China.Methods A population-based retrospective study was conducted using the data from China′s Urban Basic Medical Insurance data from January 1,2012,to December 31,2016.International Classification of Diseases code and diagnoses in Chinese for PPP were used to identify cases and estimate the prevalence,incidence,and cost.Subgroup analyses were performed according to age and sex,and sensitivity analyses were conducted to evaluate the robustness of the results.Age-adjusted prevalence rates were calculated based on the 2010 national census data.Results The crude prevalence and incidence rate of PPP in 2016 were 2.730/100000(95%CI:2.218/100000-3.242/100000)and 1.556/100000(95%CI:1.154/100000-1.958/100000),and the prevalence rate of females(2.910/100000)was higher than that of males(2.490/100000,χ^(2)=97.48,P=0.001).The incidence rate of females(1.745/100000)was also higher than that of males(1.418/100000,χ^(2)=85.02,P=0.001).The age peak of incidence and prevalence of patients with PPP was in the 30-39-year age group and a small peak existed in the 0-3-year age group among people under 20 years old.From 2012 to 2016,the average number of visits was(2.44±0.04)per patient,and the total per-capita cost per year was(982.40±39.19)yuan.Conclusion In 2016,the prevalence and incidence rate of PPP in China were higher in females than in males,and the highest age peak was in the 30-39-year age group.

关 键 词：掌跖脓疱病 发病率 患病率 费用 横断面研究 

分 类 号：R753.1[医药卫生—皮肤病学与性病学] R181.3[医药卫生—临床医学]