免疫“分子机器”的金属干预  

Metal-based interventions in the immune“molecular machinery”

作　　者：于文昊 徐新喻 刘柳宜 杨影 范换换 李劼 郭子建[1,2] Wenhao Yu;Xinyu Xu;Liuyi Liu;Ying Yang;Huanhuan Fan;Jie P.Li;Zijian Guo(State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China;Chemistry and Biomedicine Innovation Center(ChemBIC),Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学化学化工学院,配位化学国家重点实验室,南京210023 [2]南京大学化学和生物医药创新研究院,南京210023

出　　处：《中国科学：化学》2024年第5期762-776,共15页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:22293050,22293051);江苏省自然科学基金(编号:BK20232020)资助项目。

摘　　要：免疫“分子机器”的识别与调控是免疫系统有序工作的关键.金属元素作为机体必需的营养物质,具有独特的化学性质,可以通过不同机制广泛地影响和干预免疫“分子机器”.本文站在细胞内、外不同的免疫“分子机器”的角度,总结了金属对免疫“分子机器”的直接干预和间接影响,阐释了不同免疫“分子机器”中金属元素的重要作用,提出了目前相关研究的不足及其历史成因.最后,本文通过分析金属干预的化学特性,提出要结合近年来新兴的研究手段从全局性、特异性和可变性等方面进行研究,为免疫“分子机器”的金属靶向干预提供了新的见解.The recognition and regulation of the“molecular machinery”in the immune system are crucial for its proper functions.Metal elements,serving as essential nutrients in the body,possess unique chemical properties that can impact on the immune“molecular machinery”through various mechanisms.This review provides a comprehensive summary of the direct interventions and indirect influences of metals on the immune“molecular machinery”inside or outside cells.It elucidates the significant role that metal elements play in various immune“molecular machinery”and identifies the limitations and historical factors that contribute to the current research.Finally,through analyzing the chemical characteristics of metal interventions,this review suggests the integration of recent emerging research approaches to explore the global,specific,and variable aspects of metal interventions in order to provide fresh insights into metalcentered targeted interventions of the immune“molecular machinery”.

关 键 词：分子机器 免疫受体 金属干预 金属免疫学 肿瘤免疫 自免疫疾病 

分 类 号：O641.3[理学—物理化学]