甘肃省人群新型冠状病毒血清流行病学调查分析  

Epidemiological analysis of serum SARS-COV-2 in Gansu province

作　　者：张慧敏[1] 梁舒[1] 姜中毅[1] 王彪 张慧[1] 蒋小娟[1] 董茂星[1] 成瑶[1] 姚进喜[1] 于德山[1] ZHANG Huimin;LIANG Shu;JIANG Zhongyi;WANG Biao;ZHANG Hui;JIANG Xiaojuan;DONG Maoxing;CHENG Yao;YAO Jinxi;YU Deshan(Gansu Center for Disease Control and Prevention,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃省疾病预防控制中心甘肃省传染病病原学重点实验室,甘肃兰州730000

出　　处：《中国病毒病杂志》2024年第2期182-188,共7页Chinese Journal of Viral Diseases

摘　　要：目的了解甘肃省人群血清新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARSCoV-2,简称新冠病毒)IgG抗体水平,为疫情防控提供重要血清学依据。方法采用整群抽样方法,于2023年2月选取甘肃省14个市/州和兰州新区,每个市/州分别选取2个县/区,按照0~<5、5~<15、15~<25、25~<60、60~<80、≥80岁6个年龄段进行抽样。对调查对象开展新型冠状病毒感染状况、疫苗接种情况等回顾性调查,同时采集调查对象外周静脉血,用化学发光法检测SARS-CoV-2 IgG抗体。分别采用χ^(2)检验和Kruskal-Wallis H检验对抗体阳性率和抗体浓度进行统计学分析。结果有效调查6238人,出现发热、咽痛等呼吸道症状者5302人,占85.00%,自诉未发病者303人,占4.86%,不清楚是否发病的占10.15%(633人)。血清SARS-CoV-2 IgG总阳性率为96.31%(6008/6238),抗体浓度(发光值)为66.99(41.83,83.49)。自诉发病组(含确诊)、自诉未发病组和不清楚是否发病组抗体阳性率分别为97.25%(5156/5302)、89.11%(270/303)和91.94%(582/633)。各市/州人群抗体阳性率差异有统计学意义(χ^(2)=87.17,P<0.05);5~<80岁人群抗体阳性率最高(97.07%,5174/5330),80岁以上老人抗体阳性率最低(90.57%,586/647),各年龄组抗体阳性率差异有统计学意义(χ^(2)=91.80,P<0.05);医护人员、学生抗体阳性率较高,分别为98.41%(806/819)和97.87%(1242/1269),不同职业抗体阳性率差异有统计学意义(χ^(2)=49.25,P<0.05)。完成新冠病毒疫苗接种2剂次及以上者5775人,占总调查人数的92.58%,5岁以下儿童全程接种率最低(28.74%,75/261),其次为80岁以上老人(85.16%,551/647),5~<80岁人群全程接种率为96.60%(5149/5330),不同年龄组间疫苗接种率差异有统计学意义(χ^(2)=1723.87,P<0.05)。自诉发病组完成接种2剂次及以上者占93.34%(4949/5302),抗体阳性率为97.25%(5156/5302);自诉未发病组全程接种率和抗体阳性率分别为86.47%(262/303)和89.11%(270/303);自诉不清�Objective To understand the levels of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)IgG antibodies in the population of Gansu province,so as to provide an important serological basis for epidemic prevention and control.Methods Two counties/districts were selected in each of the 14 cities/prefectures in Gansu province and a whole-group stratified sampling was conducted based on 6 age groups:0~<5,5~<15,15~<25,25~<60,60~<80 and≥80.A retrospective investigation was carried out on 6238 subjects on the status of SARS-COV-2 infection and vaccination among the population.Venous blood samples were collected,and SARS-CoV-2 IgG antibodies were detected using the chemiluminescence method.χ^(2) and Kruskal-Wallis H tests were used to analyze the antibody positivity rate and antibody concentration of the subjects.Results A total of 6238 subjects were effectively surveyed in Gansu province.Among them,5302 individuals,accounting for 85.00%,had respiratory symptoms such as fever and sore throat,while 303 individuals,accounting for 4.86%,denied symptoms,and 633 individuals,accounting for 10.15%,were unsure.The total positive rate of serum SARS-CoV-2 IgG was 96.31%(6008/6238),with a median antibody concentration(interquartile range)of 66.99(41.83,83.49).The antibody-positive rates of the population with onset,denial,and unknown cases were 97.25%(5156/5302),89.11%(270/303),and 91.94%(582/633),respectively.There was significant difference in the antibody-positive rate among the population in different cities and prefectures(χ^(2)=87.17,P<0.05).The antibody-positive rate of the population aged 5 to<80 was as high as 97.07%(5174/5330),while the antibody-positive rate of the elderly aged 80 and above was the lowest at 90.57%(586/647).There was a statistically significant difference in antibody-positive rates among different age groups(χ^(2)=91.80,P<0.05).The antibody-positive rates of medical staff and students were 98.41%(806/819)and 97.87%(1242/1269),which were higher than those of other professions,and the differenc

关 键 词：新型冠状病毒 奥密克戎变异株 IGG抗体 疫苗接种 血清流行病学 

分 类 号：R183.3[医药卫生—流行病学]