发热伴血小板减少综合征发病机制及诊疗研究进展  

Research progress of pathogenesis,diagnosis and treatment of severe fever with thrombocytopenia syndrome

作　　者：迪丽胡玛尔·扎衣尔 张斌[1] 朱彬 田进 黄红明 张诗雨 王俊忠 郑昕[1] 王宝菊[1] DILIHUMAER Zhayier;ZHANG Bin;ZHU Bin;TIAN Jin;HUANG Hongming;ZHANG Shiyu;WANG Junzhong;ZHENG Xin;WANG Baoju(Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院感染性疾病科,湖北武汉430022

出　　处：《中国病毒病杂志》2024年第2期189-195,共7页Chinese Journal of Viral Diseases

基　　金：国家重点研发计划(2021YFC2301803,2022YFC2305101);湖北省自然科学基金项目(创新群体项目)(2022CFA010)。

摘　　要：发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)是由发热伴血小板减少综合征病毒(severe fever with thrombocytopenia syndrome virus,SFTSV),又称大别班达病毒(Dabie bandavirus,DBV)感染所致的急性蜱媒传染病。SFTSV能够影响天然免疫和获得性免疫中的多种免疫细胞,通过细胞因子和趋化因子的释放,使机体产生发热、血小板减少、白细胞减少、器官功能损害等,甚至导致多器官衰竭而造成患者死亡。尽管目前临床上暂无针对SFTSV的具有确切疗效的抗病毒药,但积极的支持对症治疗仍能挽救大部分SFTS患者的生命。为进一步了解SFTS,并探讨有效的SFTS诊疗手段,本文针对其发病机制及最新诊疗进展予以综述。Severe fever with thrombocytopenia syndrome(SFTS)is an acute tick-borne infectious disease caused by severe fever with thrombocytopenia syndrome virus(SFTSV),also known as Dabie bandavirus(DBV).SFTSV can affect various innate and adaptive immune cells,thereby releasing various cytokines and chemokines,leading to fever,thrombocytopenia,leukopenia,organ dysfunction/failure,and ultimately death.Although there are currently no anti-viral drugs that have been proven effective in clinical practice,supportive treatment can still cure the majority of patients.In order to further understand SFTS and propose potential diagnosis and treatment methods of SFTS,this article reviews its pathogenesis and the latest therapeutic progress.

关 键 词：发热伴血小板减少综合征 发热伴血小板减少综合征病毒 新型布尼亚病毒 大别班达病毒 发病机制 治疗 

分 类 号：R512.99[医药卫生—内科学]