高迁移率族蛋白B1在临床相关疾病中的作用研究进展  

Research progress on the role of high mobility group box-1 protein in clinically relevant diseases

作　　者：曾雨竹(综述) 吴一凡 孟林红 伍行 丁文文(审校) 屈小芹 ZENG Yuzhu;WU Yifan;MENG Linhong;WU Xing;DING Wenwen;QU Xiaoqin(Department of Medicine,Jingchu University of Technology,Jingmen,Hubei 448000,China;Department of Basic Medicine,Jingchu University of Technology,Jingmen,Hubei 448000,China)

机构地区：[1]荆楚理工学院医学部,湖北荆门448000 [2]荆楚理工学院基础医学教研室,湖北荆门448000

出　　处：《现代医药卫生》2024年第10期1759-1762,1767,共5页Journal of Modern Medicine & Health

基　　金：湖北省大学生创新创业训练计划项目(S202211336039);湖北省教育厅科学研究计划资助项目(D20224301);荆楚理工学院校级科研项目(ZD202001)。

摘　　要：高迁移率族蛋白B1(HMGB1)是由巨噬细胞释放的一种具有晚期促炎作用的核蛋白。近年来,HMGB1作为一种新型炎症因子,国内外学者均对其进行了广泛研究,发现其在许多疾病中均充当炎症介质,发挥细胞因子活性,从而参与机体损伤。该文主要对HMGB1在心血管系统、肾脏、肝脏及胰腺等相关疾病中的损伤作用,以及其可能的机制进行了综述,以便为临床诊断和研究相关疾病提供依据。High mobility group box-1 protein(HMGB1)is a nuclear protein released by macrophages with late proinflammatory effect.In recent years,as a new type of inflammatory factor,HMGB1 has been widely studied by scholars at home and abroad.It has been found that this protein can act as an inflammatory mediator in many diseases,and then play a cytokine activity and participate in body damage.This article discussed the damage of HMGB1 in cardiovascular system,kidney,liver,pancreas and other related diseases and its possible mechanism,in order to provide a basis for clinical diagnosis and research of relevant diseases.

关 键 词：高迁移率族蛋白B1 高血压 病毒性肝炎 急性胰腺炎 综述 

分 类 号：R392[医药卫生—免疫学]