Th17细胞与IL-17在桥本甲状腺炎中的研究进展  

The role of Th17 cells and IL-17 in Hashimoto’s thyroiditis:Review

作　　者：高晓莉 马德寿[2] 江彤[3] 李嘉桢 GAO Xiaoli;MA Deshou;JIANG Tong;LI Jiazhen(Department of Emergency,Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000;Department of Surgical Oncology,The Affiliated Hospital of Qinghai University,Xining 810001,China;Department of Eodocrinology,The Affiliated Hospital of Qinghai University,Xining 810001,China)

机构地区：[1]郑州大学第二附属医院急诊科,河南郑州450000 [2]青海大学附属医院乳腺甲状腺外科,青海西宁810001 [3]青海大学附属医院内分泌科,青海西宁810001

出　　处：《细胞与分子免疫学杂志》2024年第4期373-377,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：青海省科技厅项目(2019-ZJ-7091)。

摘　　要：桥本甲状腺炎患者血清与甲状腺组织内17型辅助T(Th17)细胞数量增多、白细胞介素17(IL-17)水平显著升高,且Th17细胞与调节性T细胞(Treg)比例失衡。Treg比例下降导致甲状腺内免疫抑制功能降低,而Th17细胞通过分泌IL-17等调节甲状腺内促炎细胞因子表达和介导甲状腺组织纤维化参与桥本甲状腺炎的发生发展。Patients with Hashimoto’s thyroiditis had increased numbers of Th17 cells in serum and thyroid tissue,significantly elevated levels of interleukin 17(IL-17),and an imbalance in the ratio of Th17 cells to regulatory T cells(Tregs).The reduced Tregs’ratio leads to a reduction in immunosuppressive function within the thyroid gland,while Th17 cells are involved in the development of HT by regulating the expression of pro-inflammatory cytokines in the thyroid gland and mediating thyroid tissue fibrosis through the secretion of IL-17.

关 键 词：桥本甲状腺炎 17型辅助T(Th17)细胞 白细胞介素17(IL-17) 调节性T细胞(Treg) 作用机制 综述 

分 类 号：R581.4[医药卫生—内分泌] R392.12[医药卫生—内科学] G353.11[医药卫生—临床医学]