甲基化修饰调控椎间盘退变的研究进展  

Research progress of methylation modification in intervertebral disc degeneration

作　　者：韩通 田纪伟[1] HAN Tong;TIAN Jiwei(BenQ Medical Center,The Affiliated BenQ Hospital of Nanjing Medical University,Nanjing,Jiangsu 210000,China)

机构地区：[1]南京医科大学附属明基医院,江苏南京210000

出　　处：《中国临床研究》2024年第5期674-678,共5页Chinese Journal of Clinical Research

基　　金：江苏省自然科学基金面上项目(BK20201130)。

摘　　要：甲基化修饰作为表观遗传学的研究热点,通过调节基因的表达,在细胞信号转导和组织特异性分化等方面发挥着重要作用。在椎间盘的退变与修复过程中,甲基化修饰扮演着重要角色。本文综述了甲基化修饰在椎间盘退变发病机制中的作用及特点,并对其未来发展前景进行展望。Methylation modification is a hot research topic in epigenetics.It plays an important role in cell signal transduction and tissue-specific differentiation by regulating gene expression.Methylation modification also plays a significant role in intervertebral disc degeneration and repair.This article reviews the role and characteristics of methylation modification in the pathogenesis of intervertebral disc degeneration and provides an outlook for future development.

关 键 词：椎间盘退变 DNA甲基化 组蛋白甲基化 N6-甲基腺嘌呤 

分 类 号：R681.53[医药卫生—骨科学]