自体富血小板血浆椎间盘内注射治疗椎间盘源性腰痛的疗效  

Efficacy of autologous platelet-rich plasma intradiscal injection in the treatment of discogenic low back pain

作　　者：帅明 何成 赵岚 双峰 姜文华 王超 胡文文 李浩 SHUAI Ming;HE Cheng;ZHAO Lan;SHUANG Feng;JIANG Wenhua;WANG Chao;HU Wenwen;LI Hao(Department of Orthopedic Surgery,No.908 Hospital of Joint Logistics Support Force,Nanchang,Jiangxi 330002,China;不详)

机构地区：[1]联勤保障部队第九〇八医院骨科,江西南昌330002 [2]崇义县人民医院骨科,江西赣州341399

出　　处：《中国临床研究》2024年第5期735-738,共4页Chinese Journal of Clinical Research

基　　金：江西省卫健委科技计划项目(202311366)。

摘　　要：目的探讨自体富血小板血浆(PRP)椎间盘内注射对椎间盘源性腰痛(DLBP)的治疗效果。方法回顾性分析2022年1月至2023年6月于联勤保障部队第九〇八医院就诊的47例DLBP患者的临床资料。根据治疗方法分为PRP联合塞来昔布胶囊治疗组(试验组)16例和单纯塞来昔布胶囊治疗组(对照组)31例。统计治疗前、治疗后1周、治疗后1个月及6个月的腰痛视觉模拟评分(VAS)及Oswestry功能障碍指数(ODI)。结果随着治疗时间的推移,试验组VAS、ODI评分逐渐降低;对照组治疗后1周的VAS、ODI评分较治疗前降低,之后呈现逐渐上升趋势;试验组治疗后1个月、治疗后6个月VAS评分及ODI评分低于对照组(P<0.05)。结论自体PRP联合塞来昔布胶囊治疗DLBP远期疗效要优于单纯口服塞来昔布胶囊,可作为DLBP的一种有效治疗方式。Objective To investigate the efficacy of intradiscal injection of autologous platelet-rich plasma(PRP)in the treatment of discogenic low back pain(DLBP).Methods A retrospective analysis of clinical data from 47 DLBP patients treated at No.908 Hospital of Joint Logistics Support Force from January 2022 to June 2023 was conducted.Patients were divided into a PRP combined with celecoxib capsule treatment group(experimental group,n=16)and a celecoxib capsule monotherapy group(control group,n=31)based on the treatment method.The visual analogue scale(VAS)of low back pain and Oswestry disability index(ODI)scores were recorded before treatment,at 1 week,1 month,and 6 months after treatment.Results VAS scores and ODI scores in the experimental group gradually decreased over time;the VAS scores and ODI scores in the control group decreased at 1 week after treatment compared to before treatment,but then showed a gradual upward trend.The VAS scores and ODI scores in the experimental group were lower than those in the control group at 1 month and 6 months after treatment(P<0.05).Conclusion The long-term efficacy of autologous PRP combined with celecoxib capsule in treating DLBP is superior to that of celecoxib capsule monotherapy and can be considered as an effective treatment for DLBP.

关 键 词：富血小板血浆 椎间盘源性腰痛 塞来昔布 椎间盘内注射 

分 类 号：R681.5[医药卫生—骨科学]