基于国家专利数据库中药复方内服治疗斑秃的用药规律研究  

Study on the medication rule of Chinese medicine compound oral administration for the treatment of alopecia areata based on the national patent database

作　　者：崔钰桐 杨泽琳 田茸[2] 眭道顺[3] CUI Yutong;YANG Zelin;TIAN Rong;SUI Daoshun(Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China;不详)

机构地区：[1]广州中医药大学,广东广州510006 [2]成都中医药大学,四川成都610075 [3]广州中医药大学第一附属医院皮肤科,广东广州510405

出　　处：《中国临床研究》2024年第5期778-783,共6页Chinese Journal of Clinical Research

基　　金：国家自然科学基金(81973929);全国中医药创新骨干人才培训项目。

摘　　要：目的探讨斑秃专利中药复方内服用药规律,为中医药治疗斑秃及新药研发提供参考。方法检索国家知识产权局中国专利公布公告网站中治疗斑秃的专利中药复方数据,应用Microsoft Excel 2016软件建立数据库,进行药物频数、性味、归经统计;以Apriori关联规则进行建模分析;Cytoscape 3.9.1软件构建中药核心复杂网络;IBM SPSS Statistics 26.0软件对核心网络中的药物进行系统聚类分析。结果筛选得到符合要求的内服复方134项,涉及中药307味;其中内服复方高频中药有当归(76次)、熟地黄(73次)、生地黄(48次)、川芎(47次)等;药物功效以补虚类、活血化瘀类为主;中药四气以温性为主;五味以甘味、苦味为主;归经以肝、肺、肾经为主。复方高置信度关联规则以当归为主联合熟地黄、生地黄等;聚类分析得到新处方8类。结论国家内服中药复方专利治疗斑秃以补益肝肾、益气养血为主,配伍活血化瘀、清热凉血祛风药。Objective To explore the medication rules of patented Chinese medicine compounds for oral administration in treating alopecia areata(AA),and provide reference for the treatment of AA with Chinese medicine and the development of new drugs.Methods The data of patented Chinese medicine compounds for treating AA were searched from the website of China Patent Publication Announcement of the State Intellectual Property Office.Microsoft Excel 2016 software was used to establish a database,and frequency,nature,taste,and meridian tropism statistics were performed.Apriori association rule modeling analysis was conducted.Cytoscape 3.9.1 software was used to construct the core complex network of Chinese medicines.IBM SPSS Statistics 26.0 software was used for systematic cluster analysis of drugs in the core network.Results A total of 134 oral administration compound formulas meeting the requirements were screened,involving 307 Chinese herbs.Among them,the high-frequency Chinese herbs in oral administration compound formulas included Angelica Sinensis(76 times),Radix Rehmanniae Recens(73 times),Radix Rehmanniae Praeparata(48 times),and Ligusticum chuanxiong(47 times).The main effects of drugs were tonification deficiency and blood circulation,and the main nature was warmness.The main tastes were sweet and bitter,and the main meridians were liver,lung,and kidney meridians.The high confidence association rules in compound formulas mainly combined Angelica Sinensis with Radix Rehmanniae Recens,Radix Rehmanniae Praeparata,etc.Eight new prescriptions were obtained through cluster analysis.Conclusion The national patented Chinese medicine compound oral administration for treating AA mainly focuses on tonifying liver and kidney,supplementing Qi and nourishing blood,combined with promoting blood circulation,removing blood stasis,clearing heat,cooling blood,and expelling wind herbs.

关 键 词：斑秃 专利 用药规律 当归 地黄 油风 

分 类 号：R275.9[医药卫生—中西医结合]