冻伤动物模型建立的研究现状与进展  

Research status and progress of animal models of frostbite

作　　者：李鹏 曹文亮 杜文霞 杨波 汪国梁 程一钊 王博文 赵玲珑 LI Peng;CAO Wenliang;DU Wenxia;YANG Bo;WANG Guoliang;CHENG Yizhao;WANG Bowen;ZHAO Linglong(Institute of Industrial Hygiene of Ordance Industry,Xi'an,Shaanxi 710065,China)

机构地区：[1]兵器工业卫生研究所,陕西西安710065

出　　处：《中国临床研究》2024年第5期793-796,801,共5页Chinese Journal of Clinical Research

摘　　要：在寒冷地区、高原高海拔、极地环境及极端条件下,冻伤不仅引发冻伤部位红肿、疼痛,严重者还可导致坏死、截肢。建立稳定、可靠的冻伤动物模型是研究冻伤发病特点和治疗方法的基础和关键。目前国内外关于冻伤动物模型的相关研究较少,且单一的冻伤造模方法不能满足冻伤发病机理及临床救治研究的需求,因此有必要寻求更为全面、详细的冻伤造模方法。本文综述国内外冻伤动物造模方法、冻伤部位选择等相关研究进展,以期为冻伤相关研究提供理想的动物建模方法。In cold regions,plateau and high altitude,polar environment and extreme conditions,frostbite not only causes redness,swelling and pain in the frostbite site,but also leads to necrosis and amputation in severe cases.The establishment of stable and reliable animal models of frostbite is cruial to the study of the pathogenesis characteristics and treatment methods of frostbite.At present,there are few relevant research of frostbite animal model widely,and a single frostbite modeling method cannot meet the needs of the researchs of frostbite pathogenesis and clinical treatment.It is necessary to seek a more comprehensive and detailed frostbite modeling method.This article reviews the research progress of frostbite animal modeling methods and the selection of frostbite sites at home and abroad,in order to provide an ideal animal modeling method for frostbite related research.

关 键 词：冻伤 动物模型 液体浸冻法 喷雾法 冷空气法 与冷固体直接接触法 冻伤部位 

分 类 号：R332[医药卫生—人体生理学] R645[医药卫生—基础医学]