芽胞杆菌及其代谢物抑制包膜病毒感染的研究进展  

Advances in Inhibition of Enveloped Virus Infection by Bacillus and Its Metabolites

作　　者：姚俞洁 孟广勋[2,3] 韩颖颖 李娟[2,3] YAO Yu-jie;MENG Guang-xun;HAN Ying-ying;LI Juan(Schl.of Health Sci.&Engin.,Uni.of Shanghai for Sci.&Tech.,Shanghai 200093;Pasteur Inst.of Shanghai,Ctr.for Microbes,Devel.&Health,CAS Key Lab.of Mol.Virol.&Immun.,Uni.of Chinese Acad.of Sci.,Shanghai 200031;Nanjing Advanced Acad.of Life&Health,Nanjing 211135)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]中国科学院上海巴斯德研究所微生物、发育与健康研究中心中国科学院分子病毒与免疫重点实验室中国科学院大学,上海200031 [3]中科南京生命健康高等研究院,江苏南京211135

出　　处：《微生物学杂志》2024年第2期97-108,共12页Journal of Microbiology

基　　金：国家自然科学基金项目(32000077,81830049);中国科学院战略先导研究计划项目(XDB29030303);国际合作重点项目;(153831KYSB20190008);国家重点基础研究发展计划项目(2018YFA0507300);国家重点研发计划项目(2022YFC2304700);上海市科技重大专项(#2019SHZDZX02);学术带头人计划项目(#20XD1403900);江苏省创新能力建设计划(研发机构)—新型研发机构建设项目(BM2020019)。

摘　　要：包膜病毒指具有一层脂质双层膜的病毒,如流感病毒、冠状病毒等,这些包膜病毒每年在世界范围内导致许多严重的疾病,严重威胁人类健康。使用抗病毒药物是预防与治疗病毒感染的主要策略,芽胞杆菌(Bacillus)及其代谢物能够抑制多种包膜病毒的感染。本文综述了芽胞杆菌代谢的粗提物、肽、酶、胞外聚合物、小双链RNA和热灭活的枯草芽胞杆菌孢子在抗包膜病毒感染中发挥的重要作用,其机制是通过直接破坏病毒包膜、阻止膜融合、与病毒基因组RNA直接配对、催化裂解病毒RNA、激活天然免疫反应等对抗病毒,期望为包膜病毒的持续预防和治疗提供参考。Enveloped viruses refer to viruses with a lipid bilayer membrane,such as influenza viruses,coronaviruses,etc.,which cause many serious diseases worldwide annually and seriously threaten human health.The use of antiviral drugs is the main strategy for the prevention and treatment of viral infections,and Bacillus and its metabolites can in-hibit infection with a variety of enveloped viruses.This article reviews the important roles played by crude extracts,peptides,enzymes,extracellular polymers,small double-stranded RNA and heat-inactivated Bacillus subtilis spores in anti-enveloped virus infection,and the mechanism is to directly destroy the viral envelope,prevent membrane fusion,directly pair with viral genomic RNA,catalyze the lysis of viral RNA,activate the natural immune response,etc.,hopefully to provide a reference for the continuous prevention and treatment of enveloped virus.

关 键 词：包膜病毒 芽胞杆菌 代谢产物 病毒感染 抗病毒机制 

分 类 号：Q939.93[生物学—微生物学]