Recent advances on vaccines against malaria: A review  

作　　者：Shiza Malik Yasir Waheed 

机构地区：[1]Bridging Health Foundation,Rawalpindi 46000,Pakistan [2]Gilbert and Rose-Marie Chagoury School of Medicine,Lebanese American University,Byblos 1401,Lebanon [3]MEU Research Unit,Middle East University,Amman,11831,Jordan

出　　处：《Asian Pacific Journal of Tropical Medicine》2024年第4期143-159,共17页亚太热带医药杂志（英文版）

摘　　要：This review aims to summarize the currently viable vaccine strategies including the approved vaccines and the those in trials for next-generation malaria vaccines.Data on malaria vaccine development was collected through a comprehensive review.The literature search was performed using databases including Google Scholar,PubMed,NIH,and Web of Science.Various novel approaches of vaccination are being developed,including those based on radiation-attenuated strategies,monoclonal antibodies,targeted immunogenic peptides,RNA and DNA vaccines,nanoparticle-based vaccines,protein-based vaccination protocols,and whole organism-based vaccination strategies.Trials on RTS,S have entered phase Ⅲtesting,and those based on blood-stage vaccines and vaccines to interrupt malarial transmission have advanced to higher stages of trials.Mathematical modeling,combined drug and vaccine strategies,mass drug administration,polyvalent vaccine formulations,and targeted vaccination campaigns is playing an important role in malarial prevention.Furthermore,assessing coverage,accessibility,acceptability,deployment,compilation,and adherence to specific vaccination strategies in endemic regions is essential for vaccination drives against malaria.

关 键 词：Vaccines against malaria Drugs and adjuvant Malarial treatment PLASMODIUM RTS S vaccine 

分 类 号：R186[医药卫生—流行病学] R531.3[医药卫生—公共卫生与预防医学]